PREDICTIVE VALUE OF LECTIN BINDING ON BREAST-CANCER RECURRENCE AND SURVIVAL
PREDICTIVE VALUE OF LECTIN BINDING ON BREAST-CANCER RECURRENCE AND SURVIVAL
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凝集素结合对乳腺癌复发和生存的预测价值
DOI：
10.1016/s0140-6736(87)90482-x
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
S. Brooks
中科院分区：
文献类型：
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作者：
A. Leathem;S. Brooks
预测乳腺癌患者长期生存的一种新方法是检测原发肿瘤石蜡包埋切片中碳水化合物的表达。源自罗马蜗牛 Helixpomatia 的白蛋白腺的凝集素 (HPA) 与 N-乙酰氨基半乳糖寡糖的结合对于评估长期预后似乎很有价值。 179 名患者随访 15-20 年，其临床进展与其原发性乳腺癌石蜡切片 HPA 染色有关。所有患者均接受了乳房切除术，但未按病理或治疗进行分层。在绝经前患者中，进行和不进行 HPA 染色的组之间首次复发时间和生存时间均存在显着差异。 HPA 结合提供了一种额外的分期工具，有助于早期辅助治疗的决策，其优点是适用于常规固定的石蜡包埋材料。
A new approach for predicting long-term survival of breast-cancer patients is the detection of carbohydrate expression in paraffin-embedded sections of the primary tumour. The binding of a lectin (HPA), derived from the albumin gland of the Roman snail, Helixpomatia, to N-acetyl-galactosaminyl oligosaccharides appears valuable in assessing long-term prognosis. The clinical progress of 179 patients, followed-up for 15-20 years, was related to staining of paraffin sections of their primary breast cancers by HPA. All patients had had mastectomy but were not stratified by pathology or treatment. There were significant differences, in premenopausal patients, between groups with and without HPA staining in both time to first recurrence and survival time. HPA binding provides an extra tool for staging to aid decisions in early adjuvant treatment, with the advantage of being applicable to routinely fixed paraffin-embedded material.