Complicated colobomatous microphthalmia in the microphthalmic (mi/mi) mouse.
Complicated colobomatous microphthalmia in the microphthalmic (mi/mi) mouse.
复制标题
小眼 (mi/mi) 小鼠的复杂性缺损小眼症。
作者：
C. Scholtz;K. K. Chan
一项对肉桂小鼠眼睛发育的研究表明，小眼球是由于与缺损相关的继发性玻璃体形成失败所致。视网膜营养不良，但有残留的大神经节细胞群，视神经也含有神经节细胞。所有这些神经节细胞的胞质与正常对照组的视网膜神经节细胞相似。据推测，它们与视神经中的轴突进行通信。此外，在纯合子小鼠中，眼杯的外层通常会变得有色，形成视网膜组织，靠近眼睛的眼柄的背部也是如此。
A study of the development of the eye in the cinnamon mouse, homozygous for the gene for microphthalmia (mi), has shown that the microphthalmia is due to failure of secondary vitreous formation associated with a coloboma. The retina is dystrophic but there is a residual population of large ganglion cells and the optic nerve also contains ganglion cells. All these ganglion cells have cytoplasm similar to the retinal ganglion cells in the normal controls. It is postulated that they communicate with axons in the optic nerve. In addition, the outer epithelial layer of the eye cup, which normally becomes pigmented, forms retinal tissue in the homozygous mouse and this is also true of the dorsal part of the eyestalk near the eye.