Time, trust, and transparency: Lessons learned from collecting blood biospecimens for cancer research from the Asian American community
Time, trust, and transparency: Lessons learned from collecting blood biospecimens for cancer research from the Asian American community
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DOI：
10.1002/cncr.31168
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发表时间：
2018-04-01
期刊：
影响因子：
6.2
通讯作者：
Chen, Moon S., Jr.
中科院分区：
文献类型：
--
作者：
Dang, Julie H. T.;Chen, Moon S., Jr.
背景：推进癌症研究需要来自不同种族群体的生物标本。亚裔美国人癌症教育研究的目的是增加亚裔美国人捐献血液样本的数量和比例，用于癌症研究。方法作者的目标方法包括两种类型的社区参与，内接触（机构内针对亚裔美国癌症患者）和外接触（机构外针对亚裔美国人社区）。参加者接受了以语言进行的生物标本教育，并有机会捐献血液生物标本。外展参与者通过我们的社区生物标本献血活动捐献血液，而触手可及的参与者同意在他们作为病人的常规抽血过程中额外捐献一管血液。捐献的血液生物标本被纺成血清和血浆，储存在生物储存库中，或者被送到实验室检测癌症相关的风险因素。结果388名亚裔美国人捐献了1127份血液生物标本用于癌症研究。420管血浆和血清目前储存在癌症中心的生物储存库中，39管用于癌症基因组研究，668管用于表征癌症相关风险因素。过去十年，美国国家癌症研究所资助的亚裔美国人癌症意识、研究和培训网络在亚裔美国人中建立了信任和服务的基础，在此基础上，研究人员不仅能够利用关系向社区介绍生物标本贡献的想法，而且还能够在收集亚裔美国人血液生物标本的数量方面超出预期。癌症2018;124:1614-21。(c) 2018年美国癌症协会。作者讨论了文化上适当的、种族上特定的、认知上授权的社区和患者教育和推广方法，他们使用这种方法来吸引和招募388名亚裔美国人捐献1127份血液生物标本用于癌症研究。结果表明，如果有机会，亚裔美国人愿意为癌症研究捐献血液生物标本，通过投入必要的时间与社区建立信任关系，并对研究工作保持透明。
BACKGROUNDBiospecimens from racially diverse groups are needed to advance cancer research. The Asian American Cancer Education Study was developed to increase the number and proportion of blood biospecimen donations from Asian Americans for cancer research.METHODSThe authors' targeted approach included 2 types of community engagement, in-reach (within institution to Asian American patients with cancer) and outreach (external to institution to the general Asian American community). Participants received in-language biospecimen education followed by the opportunity to donate blood biospecimens. Outreach participants donated through our community biospecimen blood drives, and in-reach participants consented to donating an extra tube of blood during their routine blood draws as a patient. Donated blood biospecimens were spun down to serum and plasma to be stored in a biorepository or were sent to the laboratory to test for cancer-related risk factors.RESULTSThree hundred eighty-eight Asian Americans donated 1127 blood biospecimens for cancer research. Four hundred twenty tubes of plasma and serum are currently being stored at the cancer center's biorepository, 39 tubes have been used for cancer genomic research, and 668 tubes were used to characterize cancer-related risk factors.CONCLUSIONSBuilding upon the past decade of the National Cancer Institute-funded Asian American Network for Cancer Awareness, Research, and Training's foundation of trust and service among Asian Americans, researchers were able to leverage relationships not only to introduce the idea of biospecimen contribution to the community but to also exceed expectations with regard to the quantity of blood biospecimens collected from Asian Americans. Cancer 2018;124:1614-21. (c) 2018 American Cancer Society.The authors discuss the culturally appropriate, ethnically specific, and cognitively empowering community and patient education and outreach approach they use to engage and recruit 388 Asian Americans to donate 1127 blood biospecimens for cancer research. The results indicate that, by committing the time necessary to develop a trusting relationship with the community and by being transparent about research endeavors, Asian Americans will donate blood biospecimens for cancer research if given the opportunity.