Diabetes and tuberculosis: a review of the role of optimal glycemic control.
Diabetes and tuberculosis: a review of the role of optimal glycemic control.
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DOI：
10.1186/2251-6581-11-28
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发表时间：
2012-12-20
影响因子：
2.8
通讯作者：
Kalra S
中科院分区：
文献类型：
--
作者：
Niazi AK;Kalra S
发展中国家承担了糖尿病和结核病的大部分负担。这些疾病往往并存。对糖尿病控制不佳使患者易患结核病，并且是对抗结核治疗反应不良的常见原因之一。结核病还通过引起高血糖症和引起葡萄糖耐量受损而影响糖尿病。葡萄糖耐量受损是发展糖尿病的主要危险因素之一。用于治疗结核病的药物（特别是利福平和异烟肼）与口服抗糖尿病药物相互作用，可能导致血糖控制不佳。同样，一些较新的口服抗糖尿病药物可能与抗结核药物相互作用，降低其疗效。因此，糖尿病和结核病在多个层面上相互作用-每一个都使另一个恶化。合并结核病和糖尿病的患者的管理不同于单独的疾病。本文综述了糖尿病和结核病之间的关系，并提出了适当的管理这些条件。
Developing countries shoulder most of the burden of diabetes and tuberculosis. These diseases often coexist. Suboptimal control of diabetes predisposes the patient to tuberculosis, and is one of the common causes of poor response to anti-tubercular treatment. Tuberculosis also affects diabetes by causing hyperglycemia and causing impaired glucose tolerance. Impaired glucose tolerance is one of the major risk factors for developing diabetes. The drugs used to treat tuberculosis (especially rifampicin and isoniazid) interact with oral anti-diabetic drugs and may lead to suboptimal glycemic control. Similarly some of the newer oral anti-diabetic drugs may interact with anti-tuberculosis drugs and lower their efficacy. Therefore diabetes and tuberculosis interact with each other at multiple levels – each exacerbating the other. Management of patients with concomitant tuberculosis and diabetes differs from that of either disease alone. This article reviews the association between diabetes and tuberculosis and suggests appropriate management for these conditions.