Epidemiology of sarcopenia and insight into possible therapeutic targets.
Epidemiology of sarcopenia and insight into possible therapeutic targets.
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DOI：
10.1038/nrrheum.2017.60
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Cooper C
中科院分区：
文献类型：
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作者：
Dennison EM;Sayer AA;Cooper C
肌肉减少症是一种年龄相关综合征，其特征为骨骼肌质量和强度的进行性和全身性损失;它是老年人身体虚弱、功能障碍、健康相关生活质量差和过早死亡风险的主要原因。许多不同的定义已被用来描述肌肉减少症，并导致不同的估计患病率的条件。最近的定义尝试试图整合有关肌肉质量，力量和身体功能的信息，并提供一个在研究和临床环境中都有用的定义。这篇综述着重于三个不同的生理组成部分的少肌症的流行病学，并强调其模式的变化与年龄，性别，地理和时间之间的相似性和差异;和选择性集群与肌肉质量，力量和身体功能的个人风险因素。还将描述用于测量肌肉质量、力量和身体功能的方法，以及这些方法的差异如何导致患病率的变化。本综述的证据是通过对文献进行系统检索收集的。在这篇评论中描述的肌肉质量，力量和功能的描述性特征指出，迫切需要一个共识的定义，将这些参数的肌肉减少症。
Sarcopenia is an age-related syndrome characterised by progressive and generalised loss of skeletal muscle mass and strength; it is a major contributor to the risk of physical frailty, functional impairment in older people, poor health-related quality of life, and premature death. Many different definitions have been used to describe sarcopenia and have resulted in varying estimates of prevalence of the condition. The most recent attempts of definitions have tried to integrate information on muscle mass, strength and physical function and provide a definition that is useful in both research and clinical settings. This review focuses on the epidemiology of the three distinct physiological components of sarcopenia, and highlights the similarities and differences between their patterns of variation with age, gender, geography and time; and the individual risk factors that cluster selectively with muscle mass, strength and physical function. Methods used to measure muscle mass, strength and physical functioning and how differences in these approaches can contribute to the varying prevalence rates will also be described. The evidence for this review was gathered by undertaking a systematic search of the literature. The descriptive characteristics of muscle mass, strength and function described in this review point to the urgent need for a consensual definition of sarcopenia incorporating these parameters.