CIRCULATING 1ALPHA,25-DIHYDROXYVITAMIN-D IN CHICKEN - ENHANCEMENT BY INJECTION OF PROLACTIN AND DURING EGG-LAYING
CIRCULATING 1ALPHA,25-DIHYDROXYVITAMIN-D IN CHICKEN - ENHANCEMENT BY INJECTION OF PROLACTIN AND DURING EGG-LAYING
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DOI：
10.1016/0024-3205(76)90083-7
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发表时间：
1976-01-01
期刊：
影响因子：
6.1
通讯作者：
MACINTYRE, I
中科院分区：
文献类型：
--
作者：
SPANOS, E;PIKE, JW;MACINTYRE, I
为了研究催乳素对维生素D代谢的可能调节，循环1 α，25-二羟维生素D（1 α，25-（OH）2D）的放射受体测定。在100 μ g/天的剂量下，催乳激素引起血浆1 α增加2倍，25-（OH）2D。这种效应可以解释催乳素在产生高钙血症中的已知作用，并且在鸟类中可能具有重要的生理学意义。产蛋母鸡代表一种生理状态，其中已知钙吸收被刺激，并且据报道催乳素升高。血清1 α的测定，25-（OH）2D在产蛋鸡中表现出比非产蛋鸡对照组高9倍。由于在产卵期间这种显著的增加至少部分地通过注射催乳素来模拟，因此升高的催乳素和1 α之间可能存在因果关系，建议使用25-（OH）2D。
In order to investigate possible modulation of vitamin D metabolism by prolactin, circulating 1.alpha.,25-dihydroxyvitamin D (1.alpha.,25-(OH)2D) was measured by radioreceptor assay in chicks given injections of prolactin for 5 days. At a dose of 100 .mu.g/day, the lactogenic hormone elicited a 2-fold increase in plasma 1.alpha.,25-(OH)2D. This effect may explain the known action of prolactin in producing hypercalcemia and could be physiologically important in birds. The laying hen represents a physiologic state in which Ca absorption is known to be stimulated and prolactin has been reported to be elevated. Assay of serum 1.alpha.,25-(OH)2D in the laying hen demonstrates a 9-fold enhancement over non-laying controls. Since this marked increase during egg laying is at least partially mimicked by injecting prolactin, a possible causative relationship between elevated prolactin and 1.alpha.,25-(OH)2D is suggested.