Association of Common Variants in the IL-33/ST2 Axis with Ischemic Stroke
Association of Common Variants in the IL-33/ST2 Axis with Ischemic Stroke
复制标题
IL-33/ST2 轴常见变异与缺血性中风的关联。
DOI：
10.2174/1567202616666191029112334
复制
发表时间：
2019-01-01
影响因子：
2.1
通讯作者：
Song, Bo
中科院分区：
文献类型：
--
作者：
Li, Shuo;Wang, Zhijie;Song, Bo
背景资料：近年来研究发现，血清白细胞介素33（IL 33）及其受体ST 2是心血管疾病易感性的潜在生物标志物。然而，IL-33/ST 2轴与心血管疾病的遗传关联仍然存在争议。Objective：我们的目的是探讨IL-33/ST 2轴常见变异与中国汉族人群缺血性卒中之间的关联。使用改进的多重连接酶检测反应平台对IL-33/ST 2轴内的8个单核苷酸多态性（SNP）进行基因分型。在基因型和单倍型水平上分析SNP与缺血性脑卒中的相关性。结果：二元Logistic回归分析表明，rs 10435816与缺血性脑卒中的发生有显著性差异（P <0.05），rs 10435816与缺血性脑卒中的发生有显著性差异（P <0.05）。（加性模型：比值比[OR]=0.72，95%置信区间[CI]，0.54-0.95;隐性模型：012=0.72，95%CI，0.56 ± 0.94）与调整混杂因素后缺血性卒中风险降低相关。亚组分析表明，rs 10435816（加性模型：012=0.61，95%CI，0.41-0.89;隐性模型：012=0.56，95%CI，0.40-0.80），rs7025417（相加模型：012=0.57，95%CI，0.39-0.83），rs 11792633（加性模型：012=0.66，95%CI，0.46-0.95;隐性模型：012=0.67，95%CI，0.49-0.93），和rs7044343（加性模型：012=0.69，95%CI，0.48-0.97;隐性模型：012=0.67，95%CI，0.49-0.91）与调整混杂因素后大动脉粥样硬化卒中风险降低相关。我们的研究结果表明，在中国汉族人群中，IL-33/ST 2轴的常见变异与缺血性卒中风险降低之间存在相关性。
Background: Recent studies have reported that the levels of serum interleukin-33 (IL33) and its receptor, suppression of tumorigenicity 2 (ST2), are potential biomarkers for susceptibility of cardiovascular diseases. However, the genetic association of the IL-33/ST2 axis with cardiovascular diseases remains controversial.Objective: We aimed to investigate the association between common variants in the IL-33/ST2 axis and ischemic stroke in the Han Chinese population.Methods: We consecutively enrolled 1166 patients with ischemic stroke and 1079 age- and gender-matched controls. Eight single nucleotide polymorphisms (SNPs) within IL-33/ST2 axis were genotyped using the improved Multiple Ligase Detection Reaction platform. We analyzed the association between the tested SNPs and ischemic stroke at both the genotype and haplotype levels.Results: Binary logistic regression analysis indicated that rs10435816 (additive model: odds ratio [OR]=0.72, 95% confidence interval [CI], 0.54-0.95; recessive model: 012=0.72, 95%CI, 0.560.94) was associated with a decreased risk of ischemic stroke after adjustment of confounding factors. Subgroup analysis indicated that rs10435816 (additive model: 012=0.61, 95%CI, 0.41-0.89; recessive model: 012=0.56, 95%CI, 0.40-0.80), rs7025417 (additive model: 012=0.57, 95%CI, 0.39-0.83), rs11792633 (additive model: 012=0.66, 95%CI, 0.46-0.95; recessive model: 012=0.67, 95%CI, 0.49-0.93), and rs7044343 (additive model: 012=0.69, 95%CI, 0.48-0.97; recessive model: 012=0.67, 95%CI, 0.49-0.91) were associated with a decreased risk of large-artery atherosclerosis stroke after adjustment of confounding factors.Conclusion: Our findings suggested an association between common variants n the IL-33/ST2 axis and a decreased risk of ischemic stroke in the Han Chinese population.