A pilot study to investigate the induction and manipulation of learned helplessness in healthy adults.
A pilot study to investigate the induction and manipulation of learned helplessness in healthy adults.
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DOI：
10.1016/j.psychres.2014.05.045
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发表时间：
2014-11-30
影响因子：
11.3
通讯作者：
George MS
中科院分区：
文献类型：
--
作者：
Taylor JJ;Neitzke DJ;Khouri G;Borckardt JJ;Acierno R;Tuerk PW;Schmidt M;George MS
消除有害刺激的可控性可能会导致习得性无助（LH），类似于抑郁症和创伤后应激障碍（PTSD）。本研究旨在探讨是否重复经颅磁刺激（rTMS）的左背外侧前额叶皮层（DLPFC）促进LH的厌恶刺激模型的弹性。所有55名参与者都被告知，按下一系列未公开的按钮将终止他们前臂上的厌恶刺激。事实上，只有一半的人有控制权（+C）。另一半没有控制（-C）。所有参与者在范式（+C/R，-C/S，+C/S，-C/R）期间接受真实的（R）或假（S）左侧DLPFC rTMS。我们评估了LH的认知效果使用的字谜任务。LH范式成功地降低了−C组的控制感。正如预测的那样，+C/R和+C/S组比−C/S组更容易放弃，解决每个变位词所需的时间也更少。−C/R组的上级变位词表现接近统计学显著性。我们的初步研究结果表明，操纵的厌恶刺激的可控性可能会引起LH的影响，表现为受损的变位表现。需要进一步的研究来完善这个模型，并确定DLPFC rTMS是否减轻了任何LH效应。
Eliminating the controllability of a noxious stimulus may induce a learned helplessness (LH) that resembles aspects of depression and post-traumatic stress disorder (PTSD). This study examined whether repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) promotes resilience in an aversive stimulus model of LH. All 55 participants were told that an undisclosed sequence of button presses would terminate an aversive stimulus on their forearm. In truth, only half had control (+C). The other half had no control (−C). All participants received real (R) or sham (S) left DLPFC rTMS during the paradigm (+C/R, −C/S,+C/S, −C/R). We evaluated the cognitive effects of LH using an anagram task. The LH paradigm successfully reduced perceived control in the −C groups. As predicted, the +C/R and +C/S groups tended to give up less quickly and take less time to solve each anagram than did the −C/S group. Superior anagram performance in the −C/R group approached statistical significance. Our preliminary results suggest that manipulating the controllability of an aversive stimulus may induce a LH effect that manifests as impaired anagram performance. Further research is needed to refine this model and determine if DLPFC rTMS mitigates any LH effects.
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DOI：
10.4088/jcp.08m04638blu
发表时间：
2010-08
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Boggio PS;Rocha M;Oliveira MO;Fecteau S;Cohen RB;Campanhã C;Ferreira-Santos E;Meleiro A;Corchs F;Zaghi S;Pascual-Leone A;Fregni F
通讯作者：
Fregni F
DOI：
10.1073/pnas.0908563106
发表时间：
2009-10-20
影响因子：
11.1
作者：
Hains, Avis Brennan;Vu, Mai Anh T.;Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
DOI：
10.1073/pnas.0505210102
发表时间：
2005-12-20
影响因子：
11.1
作者：
deCharms, RC;Maeda, F;Mackey, SC
通讯作者：
Mackey, SC
影响因子：
4.6
作者：
GATCHEL, RJ;PROCTOR, JD
通讯作者：
PROCTOR, JD
影响因子：
--
作者：
George, Mark S.;Lisanby, Sarah H.;Sackeim, Harold A.
通讯作者：
Sackeim, Harold A.