The Repeatability of Mean Defect with Size III and Size V Standard Automated Perimetry
The Repeatability of Mean Defect with Size III and Size V Standard Automated Perimetry
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DOI：
10.1167/iovs.12-10299
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发表时间：
2013-02-01
影响因子：
4.4
通讯作者：
Johnson, Chris A.
中科院分区：
文献类型：
--
作者：
Wall, Michael;Doyle, Carrie K.;Johnson, Chris A.
目的.视野的平均缺损（MD）是用于监测随时间推移的总体视野变化的全局统计指标。我们的目的是调查青光眼患者和对照组中MD及其两种临床使用策略（瑞典交互阈值算法[SITA]标准尺寸III和全阈值尺寸V）的变异性的关系。我们随机对46名青光眼患者和28名眼部健康受试者的一只眼睛进行了测试，Humphrey程序24-2 SITA标准用于III号，全阈值用于V号，在5周内各测试5次。对5次重复试验的MD进行标准差回归，并使用分位数回归来显示变异性与MD的关系。使用Wilcoxon检验比较分位数回归后两种检验方法的标准差。两种类型的回归分析显示，随着视野损害的增加，变异性增加。分位数回归显示适度较小的MD置信限。在青光眼患者中，V型尺寸的SD降低了15%（P = 0.10），在眼部健康的受试者中降低了12%（P = 0.08）。尺寸V MD的重复性似乎略优于尺寸III SITA测试。当使用MD来确定视野进展时，需要1.5至4分贝（dB）的变化才能超出正常的95%置信限，这取决于刺激的大小和视野损伤的量。（Invest Ophthalmol维斯科学。2013;54：1345-1351）DOI：10.1167/iovs.12-10299
PURPOSE. The mean defect (MD) of the visual field is a global statistical index used to monitor overall visual field change over time. Our goal was to investigate the relationship of MD and its variability for two clinically used strategies (Swedish Interactive Threshold Algorithm [SITA] standard size III and full threshold size V) in glaucoma patients and controls.METHODS. We tested one eye, at random, for 46 glaucoma patients and 28 ocularly healthy subjects with Humphrey program 24-2 SITA standard for size III and full threshold for size V each five times over a 5-week period. The standard deviation of MD was regressed against the MD for the five repeated tests, and quantile regression was used to show the relationship of variability and MD. A Wilcoxon test was used to compare the standard deviations of the two testing methods following quantile regression.RESULTS. Both types of regression analysis showed increasing variability with increasing visual field damage. Quantile regression showed modestly smaller MD confidence limits. There was a 15% decrease in SD with size V in glaucoma patients (P = 0.10) and a 12% decrease in ocularly healthy subjects (P = 0.08).CONCLUSIONS. The repeatability of size V MD appears to be slightly better than size III SITA testing. When using MD to determine visual field progression, a change of 1.5 to 4 decibels (dB) is needed to be outside the normal 95% confidence limits, depending on the size of the stimulus and the amount of visual field damage. (Invest Ophthalmol Vis Sci. 2013;54:1345-1351) DOI:10.1167/iovs.12-10299