ParameciumDB: a community resource that integrates the Paramecium tetraurelia genome sequence with genetic data.
ParameciumDB: a community resource that integrates the Paramecium tetraurelia genome sequence with genetic data.
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Parameciumdb：一种将三尿素基因组序列与遗传数据相结合的社区资源。
DOI：
10.1093/nar/gkl777
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
中科院分区：
文献类型：
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作者：
ParameciumDB () 是一个与单细胞真核生物四尿草履虫基因组测序项目相关的新模式生物数据库。草履虫数据库采用通用模式生物数据库 (GMOD) 项目的核心组件构建，目前包含基因组序列和注释，并与可用的遗传数据（包括 Gif 草履虫种群集合）相关联。因此，可以通过基因和等位基因在序列和库存之间进行导航。根据实体-属性-值模型，使用受控词汇捕获突变菌株和通过 RNA 干扰获得的敲低表型。 ParameciumDB 目前支持浏览表型、等位基因和种群，以及查询序列特征（基因、UniProt 匹配、InterPro 域、基因本体术语）和遗传数据（表型、种群、RNA 干扰实验）。表格允许提交 RNA 干扰数据，并且提供一些生物信息学服务。未来的 ParameciumDB 开发计划包括协调研究界成员对近 40000 个基因模型的人类管理。
ParameciumDB () is a new model organism database associated with the genome sequencing project of the unicellular eukaryote Paramecium tetraurelia. Built with the core components of the Generic Model Organism Database (GMOD) project, ParameciumDB currently contains the genome sequence and annotations, linked to available genetic data including the Gif Paramecium stock collection. It is thus possible to navigate between sequences and stocks via the genes and alleles. Phenotypes, of mutant strains and of knockdowns obtained by RNA interference, are captured using controlled vocabularies according to the Entity-Attribute-Value model. ParameciumDB currently supports browsing of phenotypes, alleles and stocks as well as querying of sequence features (genes, UniProt matches, InterPro domains, Gene Ontology terms) and of genetic data (phenotypes, stocks, RNA interference experiments). Forms allow submission of RNA interference data and some bioinformatics services are available. Future ParameciumDB development plans include coordination of human curation of the near 40 000 gene models by members of the research community.