Association between vestibular function and rotational spatial orientation perception in older adults
Association between vestibular function and rotational spatial orientation perception in older adults
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DOI：
10.3233/ves-201582
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发表时间：
2021-01-01
影响因子：
2.3
通讯作者：
Agrawal, Y.
中科院分区：
文献类型：
--
作者：
Anson, E.;Ehrenburg, M. R.;Agrawal, Y.
背景：空间定向是一个复杂的过程，涉及前庭感觉输入和可能的认知能力。先前的研究表明，对于患有严重双侧前庭功能障碍的个体，旋转空间定向更差。目的：确定旋转和线性前庭功能是否与健康老龄化中的大幅旋转空间定向知觉独立相关。方法：对参与巴尔的摩的 272 名健康社区居民进行旋转空间定向准确性和前庭功能测试 [前庭眼反射 (VOR)、眼和颈部前庭诱发肌源电位 (VEMP)]老龄化的纵向研究。使用混合模型多元线性回归，我们在控制旋转大小、年龄和性别的单个模型中对外侧半规管功能、椭圆囊功能（眼部 VEMP）和囊功能（颈椎 VEMP）的空间定向误差进行回归。结果：在调整年龄和性别后，双侧 VOR 增益较低的个体（β = 20.9，p = 0 .014）和双侧椭圆囊功能缺失的个体（β = 9.32，p = 0.017）相对于前庭功能正常的个体，其空间定向误差明显更大。结论：目前的结果首次证明，双侧外侧半规管功能障碍或双侧椭圆囊功能障碍与较差的旋转空间定向相关。我们还在健康老龄化队列中证明，年龄的增长也有助于空间定向能力。
BACKGROUND: Spatial orientation is a complex process involving vestibular sensory input and possibly cognitive ability. Previous research demonstrated that rotational spatial orientation was worse for individuals with profound bilateral vestibular dysfunction.OBJECTIVE: Determine whether rotational and linear vestibular function were independently associated with large amplitude rotational spatial orientation perception in healthy aging.METHODS: Tests of rotational spatial orientation accuracy and vestibular function [vestibulo-ocular reflex (VOR), ocular and cervical vestibular evoked myogenic potentials (VEMP)] were administered to 272 healthy community-dwelling adults participating in the Baltimore Longitudinal Study of Aging. Using a mixed model multiple linear regression we regressed spatial orientation errors on lateral semicircular canal function, utricular function (ocular VEMP), and saccular function (cervical VEMP) in a single model controlling for rotation size, age, and sex.RESULTS: After adjusting for age, and sex, individuals with bilaterally low VOR gain (beta = 20.9, p =0 .014) and those with bilaterally absent utricular function (beta = 9.32, p = 0.017) made significantly larger spatial orientation errors relative to individuals with normal vestibular function.CONCLUSIONS: The current results demonstrate for the first time that either bilateral lateral semicircular canal dysfunction or bilateral utricular dysfunction are associated with worse rotational spatial orientation. We also demonstrated in a healthy aging cohort that increased age also contributes to spatial orientation ability.