Swimming into the future of drug discovery: in vivo chemical screens in zebrafish.
Swimming into the future of drug discovery: in vivo chemical screens in zebrafish.
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DOI：
10.1021/cb100029t
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发表时间：
2010-02-19
影响因子：
4
通讯作者：
Zon LI
中科院分区：
文献类型：
--
作者：
Bowman TV;Zon LI
近年来，斑马鱼体内化学筛选已成为一种快速有效地鉴定调节特定生物过程的先导化合物的方法。通过在体内进行初步筛选，从药物开发的开始就确定了生物活性、毒性和非靶向副作用。最近的一项研究表明，体内筛选可以成功地用于结构-活性关系(SAR)研究。这项工作验证了斑马鱼不仅是药物发现的有效模型，也是药物优化的有效模型。
In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure–activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.