UV light B-mediated inhibition of skin catalase activity promotes Gr-1+ CD11b+ myeloid cell expansion.
UV light B-mediated inhibition of skin catalase activity promotes Gr-1+ CD11b+ myeloid cell expansion.
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DOI：
10.1038/jid.2011.329
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发表时间：
2012-03
影响因子：
6.5
通讯作者：
Lesinski, Gregory B.
中科院分区：
文献类型：
--
作者：
Sullivan, Nicholas J.;Tober, Kathleen L.;Burns, Erin M.;Schick, Jonathan S.;Riggenbach, Judith A.;Mace, Thomas A.;Bill, Matthew A.;Young, Gregory S.;Oberyszyn, Tatiana M.;Lesinski, Gregory B.
男性的皮肤癌发病率和死亡率高于女性，但这种性别差异的原因在很大程度上仍然未知。紫外线照射诱发皮肤炎症并中和皮肤抗氧化剂。Gr-1+CD11b+骨髓细胞是异质骨髓来源的细胞，可促进炎症相关的癌变。过氧化氢酶是一种存在于皮肤中的抗氧化剂，其活性的降低与皮肤癌的发生有关。我们利用远交的、免疫能力强的Skh-1无毛小鼠模型，对紫外线B （UVB）诱导的炎症和非黑色素瘤皮肤癌进行了进一步的研究，以确定UVB诱导的炎症的性别差异。我们的研究结果表明，男性皮肤过氧化氢酶的基线活性相对较低，在两性急性UVB暴露后，过氧化氢酶活性受到抑制。进一步分析显示，皮肤过氧化氢酶活性与脾脏Gr-1+CD11b+骨髓细胞百分比呈负相关。急性UVB暴露诱导Gr-1+CD11b+骨髓细胞皮肤浸润，局部过氧化氢酶治疗在更大程度上抑制了男性的浸润。在慢性UVB研究中，我们证明了雄性荷瘤小鼠脾Gr-1+CD11b+骨髓细胞的百分比比雌性小鼠高55%。总之，我们的研究结果表明，雄性小鼠皮肤过氧化氢酶活性较低，可能至少在一定程度上导致uvb诱导的Gr-1+CD11b+骨髓细胞增加和随后的皮肤癌发生。
Skin cancer incidence and mortality are higher in men compared to women, but the causes of this sex discrepancy remain largely unknown. Ultraviolet light exposure induces cutaneous inflammation and neutralizes cutaneous antioxidants. Gr-1+CD11b+ myeloid cells are heterogeneous bone marrow-derived cells that promote inflammation-associated carcinogenesis. Reduced activity of catalase, an antioxidant present within skin, has been associated with skin carcinogenesis. We utilized the outbred, immune competent Skh-1 hairless mouse model of ultraviolet light B (UVB)-induced inflammation and non-melanoma skin cancer to further define sex discrepancies in UVB-induced inflammation. Our results demonstrated that male skin had relatively lower baseline catalase activity, which was inhibited following acute UVB exposure in both sexes. Further analysis revealed that skin catalase activity inversely correlated with splenic Gr-1+CD11b+ myeloid cell percentage. Acute UVB exposure induced Gr-1+CD11b+ myeloid cell skin infiltration, which was inhibited to a greater extent in males by topical catalase treatment. In chronic UVB studies, we demonstrated that the percentage of splenic Gr-1+CD11b+ myeloid cells was 55% higher in male tumor-bearing mice compared to their female counterparts. Together, our findings indicate that lower skin catalase activity in male mice may at least in part contribute to increased UVB-induced Gr-1+CD11b+ myeloid cells and subsequent skin carcinogenesis.
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影响因子：
4.8
作者：
Kwei, KA;Finch, JS;Bowden, GT
通讯作者：
Bowden, GT
影响因子：
15.3
作者：
Hammerberg, C;Katiyar, SK;Carroll, MC;Cooper, KD
通讯作者：
Cooper, KD
DOI：
10.1084/jem.158.3.781
发表时间：
1983-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Elmets CA;Bergstresser PR;Tigelaar RE;Wood PJ;Streilein JW
通讯作者：
Streilein JW
影响因子：
10.3
作者：
Sander, CS;Hamm, F;Thiele, JJ
通讯作者：
Thiele, JJ
影响因子：
6.5
作者：
Joosse, Arjen;de Vries, Esther;Engel, Jutta
通讯作者：
Engel, Jutta