High-density lipoprotein cholesterol associated with change in coronary plaque lipid burden assessed by near infrared spectroscopy
High-density lipoprotein cholesterol associated with change in coronary plaque lipid burden assessed by near infrared spectroscopy
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DOI：
10.1016/j.atherosclerosis.2017.08.016
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发表时间：
2017-10-01
期刊：
影响因子：
5.3
通讯作者：
Nicholls, Stephen J.
中科院分区：
文献类型：
--
作者：
Honda, Satoshi;Sidharta, Samuel L.;Nicholls, Stephen J.
背景和目标：关于血脂参数与使用体内冠状动脉成像的斑块组成的系列变化之间的关系知之甚少。本研究的目的是研究血脂和冠状动脉斑块脂质负荷的变化之间的关联评估近红外光谱（NIRS）。方法：我们进行了一系列的近红外光谱血管内超声研究49例接受冠状动脉造影的急性冠状动脉综合征（ACS）或稳定的缺血性症状。应用单变量和多变量线性回归分析评价血脂参数与最大4 mm节段脂质核心负荷指数变化之间的关系（最大LCBI 4 mm）。平均患者年龄为61 ± 9岁，29%为女性，35%有ACS临床表现，78%在基线时接受他汀类药物治疗，中位低密度脂蛋白胆固醇，高密度脂蛋白胆固醇（HDL-C）、总胆固醇和甘油三酯水平分别为101、43、174和133 mg/dL。在13个月的中位随访期间，最大LCBI 4 mm从277显著降低至194（p = 0.001）。在单变量分析中，HDL-C的百分比变化与最大LCBI 4 mm的变化呈负相关（β =-3.19，p = 0.004）。其他血脂参数与最大LCBI 4 mm变化之间无显著相关性。在多变量分析中，HDL-C的百分比变化与最大LCBI 4 mm的变化显著相关（p = 0.002）。结论：HDL-C的变化，而不是其他脂质参数，与近红外光谱评估的冠状动脉斑块脂质负荷的变化相关。这些发现强调了高密度脂蛋白对斑块组成系列变化的潜在治疗重要性。(C)2017爱思唯尔B. V.保留所有权利。
Background and aims: Little is known about the relation between serum lipid parameters and serial change in plaque composition using in vivo coronary imaging. The aim of this study was to examine the association between serum lipids and change in coronary plaque lipid burden assessed by near-infrared spectroscopy (NIRS).Methods: We performed serial NIRS-intravascular ultrasound studies in 49 patients who underwent coronary angiography for an acute coronary syndrome (ACS) or stable ischemic symptoms. Univariable and multivariable linear regression analyses were applied to evaluate the relationship between serum lipid parameters and change in lipid core burden index at the 4-mm maximal segment (max LCBI4mm).Results: Mean patient age was 61 +/- 9 y, 29% were women, 35% had an ACS clinical presentation, 78% received statin therapy at baseline, and median low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), total cholesterol and triglyceride levels were 101, 43, 174 and 133 mg/dL, respectively. During a median follow-up period of 13 months, max LCBI4mm significantly decreased from 277 to 194 (p = 0.001). On univariable analysis, the percent change in HDL-C negatively associated with the change in max LCBI4mm (beta = -3.19, p = 0.004). There were no significant associations between the other lipid parameters and change in max LCBI4mm. On multivariable analysis, percent change in HDL-C remained significantly associated with the change in max LCBI4mm (p = 0.002).Conclusions: Change in HDL-C, but not other lipids parameters, associated with changes in coronary plaque lipid burden assessed by NIRS. These findings highlight the potential therapeutic importance of high-density lipoprotein on serial change in plaque composition. (C) 2017 Elsevier B.V. All rights reserved.