FACILITATION OF 8-OHDPAT-INDUCED FOREPAW TREADING OF RATS BY THE 5-HT2 AGONIST DOI
FACILITATION OF 8-OHDPAT-INDUCED FOREPAW TREADING OF RATS BY THE 5-HT2 AGONIST DOI
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DOI：
10.1016/0014-2999(89)90178-7
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发表时间：
1989-02-14
影响因子：
5
通讯作者：
HYTTEL, J
中科院分区：
文献类型：
--
作者：
ARNT, J;HYTTEL, J
与5-HT2激动剂1（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷（DOI）共处理后，5-羟色胺1a （5-HT1A）激动剂8-羟基-2-（二-正丙基）四萘林（8-OHDPAT）诱导前爪踩的效力提高了20倍。DOI诱导的头抽搐被8-OHDPAT抑制。假定的5-HT-1B激动剂，1-（3-三氟甲基苯基）哌嗪（TFMPP），对DOI或8-OHDPAT的反应影响较弱。大剂量(-)-阿普萘洛尔、酮色林和利坦色林均能抑制8-OHDPAT + DOI诱导的前爪踩踏，但不受。β的影响。-肾上腺素受体拮抗剂（ICI 118.551）或5-HT3拮抗剂（ICS 205-930）。非有效剂量的(-)-阿普萘洛尔增加了酮色林和利坦色林的抑制作用。这些结果表明，在5-HT介导的两种行为反应的表达中，5-HT1A和5-HT2受体之间存在复杂而不同的相互作用。
The potency of the serotonin1A (5-HT1A) agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT), to induce forepaw treading was increased 20-fold after co-treatment with the 5-HT2 agonist, 1(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). DOI induced head twitches which were inhibited by 8-OHDPAT. The putative 5-HT-1B agonist, 1-(3-trifluoromethylphenyl)piperazine (TFMPP), had a weak effect on the responses to DOI or 8-OHDPAT. The forepaw treading induced by 8-OHDPAT plus DOI was inhibited by high doses of (-)-alprenolol, ketanserin or ritanserin, but was not influenced by the .beta.-adrenoceptor antagonist, ICI 118.551, or the 5-HT3 antagonist, ICS 205-930. A non-effective dose of (-)-alprenolol increased the inhibitory effect of ketanserin and ritanserin. These results indicate a complex and differnt interaction between 5-HT1A and 5-HT2 receptors in the expression of two behavioural responses mediated by 5-HT.