The Molecular Basis of Malignant Pleural Mesothelioma.
The Molecular Basis of Malignant Pleural Mesothelioma.
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DOI:
10.1016/j.thorsurg.2020.08.005
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发表时间:
2020-11
影响因子:
2.1
通讯作者:
Bueno R
中科院分区:
文献类型:
--
作者:
Wadowski B;De Rienzo A;Bueno R
Malignant pleural mesothelioma (MPM) is a rare, aggressive malignancy of the pleural lining associated with asbestos exposure in >80% of cases. It is characterized by molecular heterogeneity both between patients and within individual tumors. Next-generation sequencing technology and novel computational techniques have resulted in a greater understanding of the epigenetic, genetic, and transcriptomic hallmarks of MPM. This chapter will review these features and discuss the implications of advances in MPM molecular biology in clinical practice.
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