Expression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas
Expression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas
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DOI：
10.1002/(sici)1097-0215(19960410)66:2
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发表时间：
1996-04-10
影响因子：
6.4
通讯作者：
Aikou, T
中科院分区：
文献类型：
--
作者：
Chuman, Y;Sumizawa, T;Aikou, T
MRP是另一种多药耐药(MDR)基因，在某些实体瘤中可能参与另一种MDR机制。我们检测了多药耐药KB亚系(KB-8-5、KB-C2、C-A40和C-Al20)、人非小细胞肺癌(NSCLC)、胃癌和结直肠癌中MRP mRNA的表达，并与药物敏感的人KB细胞进行了比较。9例肺鳞癌中有8例MRP基因表达升高(89%)。此外，4种鳞癌(L13、18、19和20)中MRP的表达水平是KB-3-1细胞的3.6倍以上，且所有鳞癌的平均MRP mRNA表达水平均显著高于肺腺癌、结直肠癌和胃癌。这些结果表明，MRP至少在一定程度上是一些肺鳞癌耐药的原因。(C)1996年Wiley-Liss，Inc.
MRP has been identified as another multidrug-resistance (MDR) gene and may be involved in an alternative MDR mechanism in some solid tumors. We investigated the expression of MRP mRNA in multidrug-resistant KB sublines (KB-8-5, KB-C2, C-A40 and C-Al20), human non-small-cell lung carcinomas (NSCLC), gastric and colorectal carcinomas, and compared it with that in drug-sensitive human KB cells. MRP gene expression was elevated in 8 of 9 (89%) squamous-cell carcinomas of the lung. Furthermore, MRP expression in 4 squamous-cell carcinomas (L13, 18, 19 and 20) was more than 3.6 times higher than in KB-3-1 cells, and the average MRP mRNA expression level of all squamous-cell carcinomas was significantly higher than that of adenocarcinoma of the lung and of colorectal and gastric carcinomas. These results suggested that the MRP is responsible, at least in part, for drug resistance in some squamous-cell carcinomas of the lung. (C) 1996 Wiley-Liss, Inc.