Distribution of CTLA-4 polymorphisms in allergic asthma
Distribution of CTLA-4 polymorphisms in allergic asthma
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DOI：
10.1159/000095292
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发表时间：
2006-01-01
影响因子：
2.8
通讯作者：
Kusnierczyk, Piotr
中科院分区：
文献类型：
--
作者：
Jasek, Monika;Luszczek, Wioleta;Kusnierczyk, Piotr
背景：CTLA-4分子是T细胞活化的重要负调节因子。它编码在染色体2 q33上，并被发现与包括哮喘在内的几种过敏表型相关。然而，CTLA-4基因多态性与过敏性哮喘的关系仍存在争议，因此是本研究的主题。研究方法：采用PCR-RFLP技术，检测了219例波兰白种人过敏性哮喘患者和102例种族匹配的健康对照者的3种单核苷酸多态性（SNPs）-1147 C/T、-318 C/T和+49 A/G的分布。（AT）（n）微卫星多态性也在同一个体中进行了检测。结果如下：患者和对照组之间的SNPs或微卫星等位基因，基因型或单倍型频率无统计学显著差异被发现。结论：CTLA-4多态性似乎不是波兰人过敏性哮喘的危险因素。版权所有（c）2006 S. Karger AG，巴塞尔。
Background:The CTLA-4 molecule is an important negative regulator of T cell activation. It is encoded on chromosome 2q33 and found to be associated with several allergic phenotypes including asthma. However, the association of CTLA-4 gene polymorphisms with allergic asthma is still controversial and therefore was the subject of this study. Methods: By PCR-RFLP, the distribution of three single nucleoticle polymorphisms (SNPs), -1147 C/T, -318 C/T, and +49 A/G, was examined in 219 Polish Caucasoid patients diagnosed with allergic asthma and in 102 ethnically matched healthy control individuals. (AT)(n) microsatellite polymorphism was also tested in the same individuals. Results: No statistically significant differences in SNPs or microsatellite allele, genotype or haplotype frequencies between patients and controls were found. Conclusion: CTLA-4 polymorphisms do not seem to be a risk factor for allergic asthma in Poles. Copyright (c) 2006 S. Karger AG, Basel.