Dietary-induced metabolic acidosis decreases bone mineral density in mature ovariectomized ewes.
Dietary-induced metabolic acidosis decreases bone mineral density in mature ovariectomized ewes.
复制标题
饮食引起的代谢性酸中毒会降低成熟卵巢切除母羊的骨矿物质密度。
DOI：
10.1007/s00223-004-0217-7
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Turner,AS
中科院分区：
文献类型：
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作者：
MacLeay,JM;Olson,JD;Enns,RM;Les,CM;Toth,CA;Wheeler,DL;Turner,AS
饮食引起的代谢性酸中毒（DIMA）可能是骨质疏松症发生过程中的一个重要混杂因素。酸化饮食通常富含蛋白质和谷物，而水果和蔬菜含量相对较少。之前的研究尚未检验雌激素消耗和 DIMA 之间的相互作用是否对骨矿物质密度损失产生复合影响。以前的研究已成功地使用绵羊来检查骨转换和卵巢切除术的相互作用。因此，这项初步研究的目的是确定使用 DIMA 是否可以在骨骼成熟的卵巢切除 (OVX) 母羊中诱导骨矿物质密度 (BMD) 损失。
Dietary-induced metabolic acidosis (DIMA) may be a significant confounder in the development of osteoporosis. Diets that are acidifying are typically rich in proteins and grains and relatively poor in fruits and vegetables. Previous studies have not examined whether an interaction between estrogen depletion and DIMA have a compounded affect on bone mineral density loss. Sheep have been used successfully in previous studies to examine the interaction of bone turnover and ovariectomy. Therefore, the goal of this pilot study was to determine if bone mineral density (BMD) loss could be induced using DIMA in skeletally mature ovariectomized (OVX) ewes.