Changes in breathomics from a 1-year randomized smoking cessation trial of electronic cigarettes
Changes in breathomics from a 1-year randomized smoking cessation trial of electronic cigarettes
复制标题
DOI：
10.1111/eci.12651
复制
发表时间：
2016-08-01
影响因子：
5.5
通讯作者：
Polosa, Riccardo
中科院分区：
文献类型：
--
作者：
Campagna, Davide;Cibella, Fabio;Polosa, Riccardo
背景电子烟（EC）的使用是一种新兴的行为，已被证明可以帮助吸烟者减少卷烟消费。本研究的目的是说明长期变化的呼出气测量和呼吸系统症状的吸烟者邀请戒烟或减少他们的香烟消费量切换到ECs.Materials和方法前瞻性评估香烟消费量，分数一氧化氮浓度在呼出气（FeNO），呼出一氧化碳（eCO）和症状评分进行了1年的随机，健康吸烟者接受2.4%尼古丁、1.8%尼古丁或无尼古丁EC的对照试验。结果不同戒烟类型对FeNO和eCO的影响差异有统计学意义（P < 0.0001），不同戒烟类型对FeNO和eCO的影响差异无统计学意义（P> 0.05）。在戒烟者中，到第52周，FeNO（中位数和四分位数间距）从5.5（4.5-6.9）ppb升至17.7（13.3-18.9）ppb。到第52周，基线eCO（中位数和四分位距）从17（12-20）ppm降至3（1-4）ppm。在故障和还原剂中未观察到FeNO和eCO水平的显着变化。FeNO和eCO水平的改善与症状scores. Conclusions的衰减相关，邀请吸烟者切换到电子烟谁完全戒烟显示出稳定的逐步改善，他们的呼出气测量和症状评分。FeNO和eCO正常化高度支持改善呼吸健康结果，并增加了戒烟可以逆转肺部损害的概念。
Background Electronic cigarette (EC) use is an emerging behaviour that has been shown to help smokers to reduce cigarette consumption. The aim of this study was to illustrate long-term changes in exhaled breath measurements and respiratory symptoms in smokers invited to quit or reduce their cigarette consumption by switching to ECs.Materials and methods Prospective evaluation of cigarette consumption, fractional nitric oxide concentration in exhaled breath (FeNO), exhaled carbon monoxide (eCO) and symptom scores was performed in a 1-year randomized, controlled trial of 'healthy' smokers receiving 2.4% nicotine, 1.8% nicotine or no nicotine ECs. FeNO and eCO data are presented on the basis of participants' pooled continuous smoking phenotype classification (failures, reducers and quitters).Results A significant effect of quitting classification was found on FeNo and eCO at all time points (P < 0.0001). Among quitters, FeNO (medians and interquartile range) rose from 5.5 (4.5-6.9) ppb to 17.7 (13.3-18.9) ppb by week 52. Baseline eCO (medians and interquartile range) decreased from 17 (12-20) ppm to 3 (1-4) ppm by week 52. No significant changes in FeNO and eCO levels were observed in failures and reducers. Improvements in FeNO and eCO levels were correlated with attenuations in symptom scores.Conclusions Smokers invited to switch to electronic cigarettes who completely abstained from smoking showed steady progressive improvements in their exhaled breath measurements and symptom scores. FeNo and eCO normalization is highly supportive of improved respiratory health outcomes and adds to the notion that quitting from tobacco smoking can reverse harm in the lung.