ELEVATION OF CREATINE-KINASE IN AMYOTROPHIC LATERAL SCLEROSIS - POTENTIAL CONFUSION WITH POLYMYOSITIS
ELEVATION OF CREATINE-KINASE IN AMYOTROPHIC LATERAL SCLEROSIS - POTENTIAL CONFUSION WITH POLYMYOSITIS
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DOI：
10.1002/art.1780260212
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发表时间：
1983-01-01
影响因子：
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通讯作者：
GINSBURG, WW
中科院分区：
文献类型：
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作者：
HARRINGTON, TM;COHEN, MD;GINSBURG, WW
记录了 100 名肌萎缩侧索硬化症 (ALS) 患者的血清肌酐激酶 (CK) 水平。 43% 的患者 CK 浓度升高，平均水平为 240 U/l，范围为 59-1,327 U/l（男性正常 < 95 U/l，女性正常 < 59 U/l）。所有 CK 升高的患者均出现肌无力。在诊断 ALS 之前，七名患者最初被误诊为多发性肌炎，并给予高剂量皮质类固醇治疗，但没有临床获益。通过认识到 CK 水平不能用于可靠地区分 ALS 和原发性肌肉疾病（如多发性肌炎），可以避免这种诊断混乱。
Serum creatinine kinase (CK) levels were recorded in 100 patients with amyotrophic lateral sclerosis (ALS). CK concentrations were elevated in 43% of the patients, with a mean level of 240 U/l and a range of 59-1,327 U/l (male normal < 95 U/l, female normal < 59 U/l). All patients with elevated CK had muscle weakness. Seven patients were initially misdiagnosed as having polymyositis and given high dose corticosteroids without clinical benefit, prior to the diagnosis of ALS. Such diagnostic confusion can be avoided by an awareness that CK levels cannot be used to reliably differentiate between ALS and primary muscle disease such as polymyositis.