Neurochemistry of late-life major depression: A pilot two-dimensional MR spectroscopic study
Neurochemistry of late-life major depression: A pilot two-dimensional MR spectroscopic study
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DOI：
10.1002/jmri.20214
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发表时间：
2004-12-01
影响因子：
4.4
通讯作者：
Thomas, MA
中科院分区：
文献类型：
--
作者：
Binesh, N;Kumar, A;Thomas, MA
目的：评估老年重度抑郁症患者的二维局部化学位移相关光谱（L-COSY）序列。材料与方法：对33名健康老年受试者和15名老年重度抑郁症患者进行了调查。使用三个切片选择性射频 (RF) 脉冲（90、180 和 90），在以白质为主的背外侧前额叶区域选择 3 x 3 x 3 cm(3) 的体素大小。在体积定位之前使用化学位移选择性（CHESS）序列来预饱和水。二维原始数据矩阵由检测周期 (t(2)) 上的 1024 个复杂点和演化周期 (t(1)) 上的 100 个增量组成，导致每次采集的总采集时间约为 27 分钟。使用相对于 3.0 ppm 总肌酸 (Cr) 的对角线峰体积的二维峰体积计算代谢物比率。结果：在 33 名老年受试者中，男性胆碱 (Cho) 与 Cr 的平均比率比女性高 10% (P < 0.05)，这与一维 MRS 获得的早期结果一致。当对 16 名老年女性对照者和 12 名抑郁症女性患者的子样本中的代谢物比率进行比较时，抑郁症老年患者的肌醇 (mI)、磷酸乙醇胺 (PE) 和谷氨酸/谷氨酰胺 (Glx) 水平高于对照者，尽管差异不具有统计学意义。 结论：我们的初步研究表明，在老年受试者和晚年情绪障碍患者中成功进行二维 L-COSY 的可行性。这些发现与我们早期通过一维 MRS 检测到的重度抑郁症 (MDD) 的发现一致并扩展了。 (C) 2004 Wiley-Liss, Inc.
Purpose: To evaluate a two-dimensional localized chemical shift correlated spectroscopy (L-COSY) sequence in elderly patients with major depression.Materials and Methods: A total of 33 healthy elderly subjects and 15 elderly patients with major depression were investigated. A voxel size of 3 x 3 x 3 cm(3) was chosen in the dorsolateral prefrontal region with predominantly white matter, with the use of three slice-selective radiofrequency (RF) pulses (90, 180, and 90). A chemical shift-selective (CHESS) sequence was used prior to volume localization for the presaturation of water. The two-dimensional raw data matrix consisted of 1024 complex points along the detection period (t(2)), and 100 increments along the evolution period (t(1)), resulting in a total acquisition time of approximately 27 minutes per acquisition. The metabolite ratios were calculated using the two-dimensional peak volumes with respect to the diagonal peak volume of total creatine (Cr) at 3.0 ppm.Results: In the 33 elderly subjects, the mean ratio of choline (Cho) to Cr was 10% higher in men compared to women (P < 0.05), consistent with earlier findings obtained by one-dimensional MRS. When the metabolite ratios were compared in a subsample of 16 elderly female controls and 12 depressed female patients, the depressed geriatric patients had higher levels of myoinositol-(mI), phosphoethanolamine (PE), and glutamate/glutamine (Glx) than the controls, although the differences were not statistically significant.Conclusion: Our pilot study shows the feasibility of performing two-dimensional L-COSY successfully in elderly subjects and patients with late-life mood disorders. These findings are consistent with and expand on our earlier findings in major depressive disorder (MDD) detected with one-dimensional MRS. (C) 2004 Wiley-Liss, Inc.