A SIMPLE METHOD FOR ESTIMATING DERMAL ABSORPTION OF CHEMICALS IN WATER
A SIMPLE METHOD FOR ESTIMATING DERMAL ABSORPTION OF CHEMICALS IN WATER
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DOI：
10.1016/0045-6535(89)90022-2
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发表时间：
1989-01-01
期刊：
影响因子：
8.8
通讯作者：
ROSSI, JE
中科院分区：
文献类型：
--
作者：
BROWN, SL;ROSSI, JE
提出了一个半经验数学模型，用于估计皮肤吸收的化学品从稀释的水溶液，如洗澡水。吸收取决于化学品在水中的浓度、暴露的皮肤面积、暴露的时间以及渗透系数，渗透系数主要取决于材料在脂质和水中的相对溶解度，以及其他不易建模的因素。
A semiempirical mathematical model is proposed for estimating the dermal absorption of chemicals from dilute aqueous solutions, such as bath water. Absorption depends on the concentration of the chemical in water, the area of skin exposed, the time of exposure, and a permeation coefficient that depends importantly on the relative solubility of the material in lipids and water, among other factors not so easily modeled.