Genetic studies define MAGUK proteins as regulators of epithelial cell polarity.
Genetic studies define MAGUK proteins as regulators of epithelial cell polarity.
复制标题
DOI：
10.1387/ijdb.12141438
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
G. Caruana
中科院分区：
文献类型：
--
作者：
G. Caruana
极化上皮细胞在早期胚胎发育和器官发生过程中起关键作用。属于膜相关鸟苷酸激酶（MAGUK）家族的多结构域支架蛋白通常存在于极化上皮细胞的质膜上。在果蝇和秀丽隐杆线虫中的遗传研究已经揭示MAGUK蛋白调节极化上皮表型的各个方面，包括细胞连接组装、蛋白质靶向质膜和极化信号复合物的组织。本文将重点介绍遗传学研究，有助于我们了解MAGUK家族成员，Dlg和Lin-2/CASK，在控制这些过程。此外，我们最近对小鼠Dlg的遗传分析，结合其他人对Lin-2/CASK的遗传和生物化学研究，表明将Dlg和Lin-2/CASK置于相同发育途径中的模型。
Polarized epithelial cells play critical roles during early embryonic development and organogenesis. Multi-domain scaffolding proteins belonging to the membrane associated guanylate kinase (MAGUK) family are commonly found at the plasma membrane of polarized epithelial cells. Genetic studies in Drosophila melanogaster and Caenorhabditis elegans have revealed that MAGUK proteins regulate various aspects of the polarized epithelial phenotype, including cell junction assembly, targeting of proteins to the plasma membrane and the organisation of polarized signalling complexes. This review will focus on the genetic studies that have contributed to our understanding of the MAGUK family members, Dlg and Lin-2/CASK, in controlling these processes. In addition, our recent genetic analysis of mouse Dlg, in combination with genetic and biochemical studies of Lin-2/CASK by others suggests a model placing Dlg and Lin-2/CASK within the same developmental pathway.