Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa.
Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa.
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DOI：
10.1021/np9004147
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发表时间：
2010-01
影响因子：
5.1
通讯作者：
Gang Xu;W. L. T. Kan;Yan Zhou;Jing-zheng Song;Q. Han;C. Qiao;C. Cho;J. Rudd;G. Lin;
中科院分区：
文献类型：
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作者：
Gang Xu;W. L. T. Kan;Yan Zhou;Jing-zheng Song;Q. Han;C. Qiao;C. Cho;J. Rudd;G. Lin;
An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.
