Angiogenic factors are associated with multiple sclerosis
Angiogenic factors are associated with multiple sclerosis
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DOI：
10.1016/j.jneuroim.2016.11.005
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发表时间：
2016-12-15
影响因子：
3.3
通讯作者：
Keyvani, Hossein
中科院分区：
文献类型：
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作者：
Karampoor, Sajad;Zahednasab, Hamid;Keyvani, Hossein
越来越多的证据表明血管生成在多发性硬化症（MS）的发病机制中起着至关重要的作用。当血管生成过程停止时，MS动物模型显示出显著的改善。在这项研究中，我们测量了50例MS患者（包括20例新诊断患者和30例服用ifn - β 6个月的患者）和40例健康人的血清血管内皮生长因子（VEGF）、可溶性内素（sEng）、血管生成素1（Ang-1）、血管生成素2 （Ang-2）、尿酸（UA）水平以及血清抗eb病毒（EBNA-1） IgG。除尿酸酶定量酶法外，还采用酶联免疫吸附试验（ELISA）。与健康受试者相比，MS患者血清样本中VEGF、Ang-1、Ang-2和sEng显著升高。与服用干扰素- β的患者相比，新诊断的MS患者的VEGF水平更高，并与EDSS相关。与健康组相比，MS患者血清UA水平有统计学意义上的降低。MS患者的抗ebv抗体滴度高于对照组，且抗ebv滴度与血管生成因子相关。综上所述，血管生成可能在MS中起重要作用，EBV感染可能与这一现象有关。(C) 2016年Elsevier B.V.出版
A growing body of evidence suggests that angiogenesis plays a crucial role in the pathogenesis of multiple sclerosis (MS). Animal models of MS show a significant improvement when the process of angiogenesis is halted. In this study, we measured the serum levels of vascular-endothelial growth factor (VEGF), soluble Endoglin (sEng), angiopoietin 1(Ang-1), angiopoietin 2 (Ang-2), and uric acid (UA) as well as serum anti-Epstein-Barr virus (EBV) EBNA-1 IgG in 50 MS patients (including 20 newly diagnosed and 30 patients taking IFN-beta for >6 months) and 40 healthy individuals. Enzyme-linked immunosorbent assays (ELISA) were used apart from UA where the uricase quantitative enzymatic assay was used. A significant increase of VEGF, Ang-1, Ang-2, and sEng in serum samples of MS patients with respect to healthy subjects was observed. VEGF was higher in newly diagnosed MS patients in comparison to patients taking interferon-beta and was associated with EDSS. The serum levels of UA were statistically lower in MS patients as compared to the healthy group. Higher levels of anti-EBV antibody titers were seen in MS patients than controls and anti-EBV titers correlated with angiogenic factors. It seems that in summary, angiogenesis may play an important role in MS and infection with EBV might be correlated with this phenomenon. (C) 2016 Published by Elsevier B.V.