Increased risk for cervical disease progression of French women infected with the human papillomavirus type 16 E6-35OG variant
Increased risk for cervical disease progression of French women infected with the human papillomavirus type 16 E6-35OG variant
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DOI：
10.1158/1055-9965.epi-05-0864
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发表时间：
2006-04-01
影响因子：
3.8
通讯作者：
Zehbe, I
中科院分区：
文献类型：
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作者：
Grodzki, M;Besson, G;Zehbe, I
为了检验人乳头瘤病毒（HPV）16型和HPV 16 E6变异体作为病毒持续存在和进展为高级别病变的危险因素的意义，我们在一项超过15，000名法国白人女性的队列研究中进行了巢式病例对照研究。比较了感染高危型HPV的三组患者：（a）感染清除的女性（对照组，n = 201），（B）持续感染的女性（病例，n = 87），和（c）进展为高级别病变的女性（病例，n = 58）。与其他高危HPV类型相比，持续性HPV感染和进展为高级病变的女性更有可能携带HPV 16 [比值比（OR），2.4; 95%置信区间（95%CI），1.3-4.3和OR，4.2; 95%CI，分别为2.2-8.1]。值得注意的是，在携带HPV 16 350 G变异体的女性中，持续性（3.0; 95% CI，1.4-6.7）和进展性（6.2; 95% CI，2.7-14.3）的OR尤其升高。因此，HPV类型和HPV 16变异似乎是病毒持续存在和感染进展为高度宫颈病变的危险因素。
To test the significance of human papillomavirus (HPV) type 16 and HPV16 E6 variants as risk factors for viral persistence and progression to high-grade lesion, we did a nested case-control study within a cohort study of > 15,000 Caucasian French women. Three groups infected with high-risk HPV were compared: (a) women with cleared infection (controls, n = 201), (b) women with persistent infection (cases, n = 87), and (c) women who progressed into high-grade lesion (cases, n = 58). Women with persistent HPV infection and those that progressed into high-grade lesions were likelier to harbor HPV16 than other high-risk HPV types [odds ratio (OR), 2.4; 95% confidence interval (95% CI), 1.3-4.3 and OR, 4.2; 95% CI, 2.2-8.1, respectively]. Notably, especially elevated ORs of persistence (3.0; 95% CI, 1.4-6.7) and progression (6.2; 95% CI, 2.7-14.3) were found among women who harbored the HPV16 350G variant. Thus, HPV type and HPV16 variant seem to be risk factors for viral persistence and progression of infections into high-grade cervical lesions.