Factors predicting the prognosis of oral alendronate-related osteonecrosis of the jaws: A 4-year cohort study
Factors predicting the prognosis of oral alendronate-related osteonecrosis of the jaws: A 4-year cohort study
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DOI：
10.1002/hed.23235
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发表时间：
2013-12-01
影响因子：
2.9
通讯作者：
Kok, Sang-Heng
中科院分区：
文献类型：
--
作者：
Lee, Jang-Jaer;Cheng, Shih-Jung;Kok, Sang-Heng
背景关于阿伦磷酸钠相关性颌骨坏死(ONJ)的预后因素的研究很少。方法我们调查了100名骨质疏松症患者，在4年的时间里治疗了111个阿伦磷酸钠相关的ONJ病变。结果6个月累积完全缓解率为48.65%。血清骨特异性碱性磷酸酶水平和GT；10g/L，病变深度10 mm，前部病变为6个月内愈合的机会较大，调整后的危险比分别为2.48(95%可信区间，1.41~4.37)，2.71(95%可信区间，1.57~4.70)，3.94(95%可信区间，1.87~8.30)。治疗前BSAP水平越高，预后越好。(C)2013威利期刊公司Head Neck 35：1787-1795,2013
BackgroundStudies concerning prognostic factors specific for alendronate-related osteonecrosis of the jaws (ONJ) are rare.MethodsWe surveyed a cohort of 100 osteoporotic patients with 111 alendronate-related ONJ lesions treated during a 4-year period. Prognostic values of clinical variables and serum markers of bone turnover were assessed by univariate and multivariate analyses.ResultsThe cumulative complete response rate at 6 months was 48.65%. Serum bone-specific alkaline phosphatase (BSAP) level >10 g/L, lesion depth 10 mm, and lesions in anterior regions denoted a better chance of healing within 6 months and the adjusted hazard ratios were 2.48 (95% confidence interval [CI], 1.41-4.37), 2.71 (95% CI, 1.57-4.70), and 3.94 (95% CI, 1.87-8.30), respectively.ConclusionsEarly discovery of lesions and prevention of their deeper extension are crucial for improving the prognosis of alendronate-related ONJ. A higher pretreatment level of BSAP indicates a better prognosis. (c) 2013 Wiley Periodicals, Inc. Head Neck 35: 1787-1795, 2013