Serum Betatrophin Concentrations Are Significantly Increased in Overweight but not in Obese or Type 2 Diabetic Individuals
Serum Betatrophin Concentrations Are Significantly Increased in Overweight but not in Obese or Type 2 Diabetic Individuals
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DOI：
10.1002/oby.21038
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发表时间：
2015-04-01
期刊：
影响因子：
6.9
通讯作者：
Jia, Weiping
中科院分区：
文献类型：
--
作者：
Guo, Kaifeng;Lu, Junxi;Jia, Weiping
方法采用酶联免疫吸附法（ELISA）测定60例糖耐量正常者的血清betatrophin水平，并分析其与胰岛素抵抗（IR）及其他代谢指标的关系（NGT：17名瘦型受试者，23名超重受试者和20名肥胖受试者）和56名2型糖尿病受试者（T2 DM：14名瘦型受试者，23名超重受试者和19名肥胖受试者）。血清betatrophin水平与肥胖，血糖，血脂，和肝酶parameters.ResultsSerum betatrophin浓度显着较高的超重受试者在NGT和T2 DM组的协会进行了研究;然而，瘦和肥胖的参与者之间没有显着差异进行了观察。男性与女性、NGT与T2 DM之间无显著性差异。所有受试者的血清betatrophin浓度与空腹胰岛素、稳态模型评估的胰岛素抵抗（HOMA-IR）、谷氨酰转肽酶（-GT）和丙氨酸氨基转移酶（ALT）呈正相关。血清betatrophin浓度表现出独立的关联-GT和HOMA-IR.ConclusionsSerum betatrophin水平显着增加，超重的人，但不是在个人肥胖或T2 DM。血清betatrophin浓度与IR显著相关，但与血脂、血糖稳态或糖尿病无关。
ObjectiveIn this study, circulating serum betatrophin levels were quantitated and their relationships with insulin resistance (IR) and other metabolic parameters in Chinese subjects with varying degrees of obesity and glucose tolerance were examined.MethodsSerum betatrophin levels were determined using ELISA in 60 subjects with normal glucose tolerance (NGT: 17 lean, 23 overweight, and 20 obese subjects) and 56 subjects with type 2 diabetes mellitus (T2DM: 14 lean, 23 overweight, and 19 obese subjects). The associations of serum betatrophin levels with adiposity, glucose, lipid profile, and hepatic enzyme parameters were studied.ResultsSerum betatrophin concentrations were significantly higher in overweight subjects in both the NGT and T2DM groups; however, no significant difference between lean and obese participants was observed. No significant difference was found between males and females or between NGT and T2DM subjects. Serum betatrophin concentrations correlated positively with fasting insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), -glutamyl transpeptidase (-GT), and alanine aminotransferase (ALT) in all subjects. Serum betatrophin concentrations showed an independent association with -GT and HOMA-IR.ConclusionsSerum betatrophin levels were significantly increased in overweight individuals but not in individuals with obesity or T2DM. Serum betatrophin concentrations were significantly associated with IR, but not with lipid profiles, glucose homeostasis, or diabetes.