Morbidity, mortality and spatial distribution of meningococcal disease, 1974-2007
Morbidity, mortality and spatial distribution of meningococcal disease, 1974-2007
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DOI：
10.1017/s0950268809002428
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发表时间：
2009-11-01
影响因子：
4.2
通讯作者：
Molbak, K.
中科院分区：
文献类型：
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作者：
Howitz, M.;Lambertsen, L.;Molbak, K.
为了确定死亡率和后遗症的决定因素，并分析脑膜炎球菌病的空间分布，我们联系了丹麦的四个国家登记处。1974-2007年期间，登记了5 924例脑膜炎球菌病。我们的分析证实了致命性脑膜炎球菌病结局的已知风险因素，即败血症和高龄（> 50岁）。总病死率为7.6%;发现两种表型与死亡风险增加相关; C：2a：P1.2，5和B：15：P1.7，16。B：15：P1.7，16也与感知性听力损失的过度风险相关。脑膜炎球菌病的发病率在人口稠密和人口不那么稠密的地区之间是相当的，但住在离医院较远的地方的病人死于感染的风险要高得多。为了改善脑膜炎球菌病的控制，重要的是要了解强毒“成功克隆”，如C：2a：P1.2，5和B：15：P1.7，16的流行病学和致病性，并最终开发针对血清群B的疫苗。
To identify determinants for mortality and sequelae and to analyse the spatial distribution of meningococcal disease, we linked four national Danish registries. In the period 1974-2007, 5924 cases of meningococcal disease were registered. Our analysis confirms known risk factors for a fatal meningococcal disease outcome, i.e. septicaemia and high age (> 50 years). The overall case-fatality rate was 7.6%; two phenotypes were found to be associated with increased risk of death; C:2a:P1.2,5 and B:15:P1.7,16. B:15:P1.7,16 was also associated with excess risk of perceptive hearing loss. The incidence rates of meningococcal disease were comparable between densely and less densely populated areas, but patients living further from a hospital were at significantly higher risk of dying from the infection. To improve control of meningococcal disease, it is important to understand the epidemiology and pathogenicity of virulent 'successful clones', such as C:2a:P1.2,5 and B:15:P1.7,16, and, eventually, to develop vaccines against serogroup B.