The role of T-cells in the pathogenesis of myelodysplastic syndromes: Passengers and drivers
The role of T-cells in the pathogenesis of myelodysplastic syndromes: Passengers and drivers
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DOI：
10.1016/j.leukres.2012.11.007
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发表时间：
2013-02-01
影响因子：
2.7
通讯作者：
Longinotti, Maurizio
中科院分区：
文献类型：
--
作者：
Fozza, Claudio;Longinotti, Maurizio
尽管大量的临床和实验数据表明T淋巴细胞参与了骨髓增生异常综合征（MDS）的发病机制，但T细胞在这种情况下所发挥的实际作用还有待最终解剖。这篇简短的综述将试图进一步解决这一问题，通过最相关的研究探索MDS患者的T细胞库以及特定T细胞亚群（如调节性T细胞和Th17 T细胞）的潜在作用。(C)2012爱思唯尔有限公司保留所有权利。
Although a burden of clinical and experimental data suggest the involvement of T-lymphocytes in the pathogenesis of myelodysplastic syndromes (MDS), the actual weight exerted by T-cells in this scenario is yet to be conclusively dissected. This brief review will try to further address this point, by running through the most relevant studies exploring the T-cell repertoire of MDS patients as well as the potential role of specific T-cell subsets such as regulatory T-cells and Th17 T-cells. (C) 2012 Elsevier Ltd. All rights reserved.