Platelet GP IIIa PIA and GP Ib variable number tandem repeat polymorphisms and markers of platelet activation in acute stroke
Platelet GP IIIa PIA and GP Ib variable number tandem repeat polymorphisms and markers of platelet activation in acute stroke
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DOI：
10.1161/01.atv.18.7.1124
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发表时间：
1998-07-01
影响因子：
8.7
通讯作者：
Grant, PJ
中科院分区：
文献类型：
--
作者：
Carter, AM;Catto, AJ;Grant, PJ
血小板糖蛋白（GP）Ib-V-IX和IIb/IIIa复合物的许多多态性已被描述，GP IIIa的PIA多态性与冠状动脉血栓形成有关。我们测定了609例急性脑卒中患者和435例健康对照者的β-血小板球蛋白（β-TG）和血小板因子4（PF 4）水平以及PIA基因型分布和GP Ib可变数目串联重复序列（VNTR）多态性。两组患者的β-TG水平在开始时均较高（47.4 [44.7至50.2] ng/mL，P
A number of polymorphisms of the platelet glycoprotein (GP) Ib-V-IX and IIb/IIIa complexes have been described, and the PIA polymorphism of GP IIIa has been associated with coronary thrombosis. We determined the levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) and the genotype distributions of PIA and a variable number tandem repeat (VNTR) polymorphism of GP Ib in subjects with acute stroke (n=609) and healthy control subjects (n=435). Levels of beta-TG were higher in patients both initially (47.4 [44.7 to 50.2] ng/mL, P