Biofunctional rapid prototyping for tissue-engineering applications:: 3D bioplotting versus 3D printing
Biofunctional rapid prototyping for tissue-engineering applications:: 3D bioplotting versus 3D printing
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DOI：
10.1002/pola.10807
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发表时间：
2004-02-01
影响因子：
--
通讯作者：
Mülhaupt, R
中科院分区：
文献类型：
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作者：
Pfister, A;Landers, R;Mülhaupt, R
比较了两种重要的快速成型技术（3D打印和3D生物绘图）在满足组织工程应用需求的生物可降解聚氨酯支架的计算机辅助设计和自由形状制造方面的优缺点。脂肪族聚氨酯是基于赖氨酸乙酯二异氰酸酯和异佛洛酮二异氰酸酯。通过3D打印对支架进行逐层构建，即将淀粉颗粒粘接在一起，然后将淀粉与赖氨酸乙酯二异氰酸酯进行浸渍和部分交联。另外，3D生物标绘工艺允许三维分配和反应性处理由异佛尔酮二异氰酸酯、低聚环氧乙烷和甘油衍生的低聚醚聚氨酯。通过x射线显微断层扫描、扫描电镜和力学测试对支架进行了表征。将成骨细胞样细胞植入这种支架上，以证明其在组织工程中的潜力。(C) 2003 Wiley期刊有限公司
Two important rapid-prototyping technologies (3D Printing and 3D Bioplotting) were compared with respect to the computer-aided design and free-form fabrication of biodegradable polyurethane scaffolds meeting the demands of tissue-engineering applications. Aliphatic polyurethanes were based on lysine ethyl ester diisocyanate and isophorone diisocyanate. Layer-by-layer construction of the scaffolds was performed by 3D Printing, that is, bonding together starch particles followed by infiltration and partial crosslinking of starch with lysine ethyl ester diisocyanate. Alternatively, the 3D Bioplotting process permitted three-dimensional dispensing and reactive processing of oligoetherurethanes derived from isophorone diisocyanate, oligoethylene oxide, and glycerol. The scaffolds were characterized with X-ray microtomography, scanning electron microscopy, and mechanical testing. Osteoblast-like cells were seeded on such scaffolds to demonstrate their potential in tissue engineering. (C) 2003 Wiley Periodicals, Inc.