STRESS AND LIPOPROTEIN METABOLISM - MODULATORS AND MECHANISMS
STRESS AND LIPOPROTEIN METABOLISM - MODULATORS AND MECHANISMS
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DOI：
10.1016/0026-0495(93)90255-m
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发表时间：
1993-09-01
影响因子：
9.8
通讯作者：
SUAREZ, EC
中科院分区：
文献类型：
--
作者：
BRINDLEY, DN;MCCANN, BS;SUAREZ, EC
甘油三酯和低密度脂蛋白（LDL）胆固醇浓度升高，1特别是与低浓度高密度脂蛋白（HDL）胆固醇2结合时，与动脉粥样硬化、冠心病和中风风险增加相关。虽然一些饮食和遗传因素有助于致动脉粥样硬化的脂蛋白谱，3，4压力也有助于脂蛋白的不利浓度，可能易患心血管疾病。5，6本报告回顾了支持压力和脂质代谢之间联系的数据，特别关注压力可能与脂质浓度增加相关的机制，以及几个可以调节压力和脂质水平之间关系的因素。在简要讨论压力之后，本报告分为三个主要部分。首先，考虑支持压力和脂蛋白代谢之间关系的数据。回顾了实验室研究、情景性和慢性压力研究、个性研究以及动物文献实验的数据。第二个主要部分讨论的机制，可以解释压力对脂蛋白代谢的影响。本节讨论了应激的代谢效应、应激对血液浓缩的影响，以及对应激的行为反应可能影响脂质浓度。最后一个主要部分回顾了压力-脂质关系的各种调节剂，包括干预个性变量，性别，饮食，脂蛋白浓度的季节性变化，遗传学和多态性。本审查报告的结论意见涉及若干有希望进一步研究的领域。
Elevated concentrations of triglycerides and low-density lipoprotein (LDL) cholesterol,1especially in combination with low concentrations of high-density lipoprotein (HDL) cholesterol,2are associated with an increased risk of atherosclerosis, coronary heart disease, and stroke. While several dietary and genetic factors contribute to atherogenic lipoprotein profiles,3,4stress also contributes to unfavorable concentrations of lipoproteins that may predispose to cardiovascular disease.5,6This report reviews the data supporting a link between stress and lipid metabolism, with particular focus on the mechanisms whereby stress could be related to increased lipid concentrations, and several factors which could modulate a relationship between stress and lipid levels. Following a brief discussion of stress, this report is divided into three main sections. First, data that support a relationship between stress and lipoprotein metabolism are considered. Data from laboratory studies, studies of episodic and chronic stress, studies on personality, and experiments from the animal literature are reviewed. The second major section discusses mechanisms that could account for stress effects on lipoprotein metabolism. This section considers the metabolic effects of stress, the effects of stress on hemoconcentration, and behavioral responses to stress that could affect lipid concentrations. The final major section reviews various modulators of the stress-lipid relationship, including intervening personality variables, gender, diet, seasonal variations in lipoprotein concentrations, and genetics and polymorphism. The concluding comments in this review address several promising areas for further research.