Effects of Cα-methyl substitution on the conformation of linear GnRH antagonist analogs
Effects of Cα-methyl substitution on the conformation of linear GnRH antagonist analogs
复制标题
Cα-甲基取代对线性 GnRH 拮抗剂类似物构象的影响
DOI：
10.1111/j.1399-3011.1994.tb00546.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
R. Roeske
中科院分区：
文献类型：
--
作者：
M. Liff;K. Kopple;Z. Tian;R. Roeske
We have examined the effect of C α -methyl groups on the conformational ensemble of GnRH analog peptides by comparing 1 2D NMR data from two analogs, Ac-D-Nal 1 -D-4-Cl-C α -Me-Phe 2 -D-Pal 3 -Ser 4 -Tyr 5 -D-Arg 6 -Leu 7 -Arg 8 -Pro 9 -D-Ala 10 -NH 2 (1) and Ac-D-Nal 1 -D-4-Cl-C α -Me-Phe 2 -D-Pal 3 -Ser 4 -C α -Me-Tyr 5 -D-Arg 6 -Leu 7 -C α -Me-Arg 8 -Pro 9 -D-Ala 10 -NH 2 (2). The two additional C α -methyl groups in residues 5 and 8 of 2 do not influence significantly the pattern of the observable main chain NOE intensities, or of the backbone HN proton chemical shifts, which indicates that they do not produce global changes in the conformational ensemble of the peptide. A local change induced by the substitution was observed in the conformation at D-Arg 8 -Pro 9
DOI：
10.1111/j.1399-3011.1991.tb00757.x
发表时间：
1991
期刊：
International journal of peptide and protein research
影响因子：
--
作者：
Tian,ZP;Roeske,RW
通讯作者：
Roeske,RW