The life cycle of C-myc - From synthesis to degradation
The life cycle of C-myc - From synthesis to degradation
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DOI：
10.4161/cc.3.9.1145
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发表时间：
2004-09-01
期刊：
影响因子：
4.3
通讯作者：
Sears, RC
中科院分区：
文献类型：
--
作者：
Sears, RC
c-Myc转录因子是细胞增殖和细胞命运决定的有效调节因子。精确调节c-Myc蛋白水平对于维持正常细胞功能至关重要。为了维持适当的c-Myc水平，其蛋白质稳定性受到严格控制。c-Myc通过泛素-蛋白酶体途径降解。这个观点讨论了一个复杂的信号通路，控制c-Myc的生命周期，从蛋白质合成到泛素介导的降解。该途径涉及Ras激活的激酶、Pin 1脯氨酰异构酶、PP 2A磷酸酶和一系列控制其稳定性的c-Myc磷酸化和去磷酸化事件。
The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated kinases, the Pin1 prolyl isomerase, the PP2A phosphatase and a series of c-Myc phosphorylation and dephosphorylation events that control its stability.