Injectable Self-Healing Hydrogel via Biological Environment-Adaptive Supramolecular Assembly for Gastric Perforation Healing.
Injectable Self-Healing Hydrogel via Biological Environment-Adaptive Supramolecular Assembly for Gastric Perforation Healing.
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DOI：
10.1021/acsnano.1c01199
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发表时间：
2021-05
期刊：
影响因子：
17.1
通讯作者：
Wenda Wang;Zicheng Zeng;Li Xiang;Cong Liu;Diana Diaz-Dussan;Zunguo Du;A. B. Asha;Wenshuai Yang;Yi-Yang Peng;Mingfei Pan;R. Narain;Jifang Liu;Hongbo Zeng
中科院分区：
文献类型：
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作者：
Wenda Wang;Zicheng Zeng;Li Xiang;Cong Liu;Diana Diaz-Dussan;Zunguo Du;A. B. Asha;Wenshuai Yang;Yi-Yang Peng;Mingfei Pan;R. Narain;Jifang Liu;Hongbo Zeng
开发有效的内创面敷料材料对术后组织再生具有重要意义，但由于传统材料对生物环境的适应性较差，因此仍是一项挑战。在此，我们报道了一种基于胃环境适应性超分子组装的可注射自愈水凝胶的例子，并探索了其在胃穿孔愈合中的应用。通过利用胃环境调节的超分子相互作用，自组装的水凝胶网络具有敏感的温度响应性、可注射性、可印刷性和快速自我修复能力。该水凝胶敷料能有效地抑制微生物的附着，表现出优异的抗生物污损性能。活体大鼠模型进一步证明，与常规治疗相比，制备的水凝胶敷料简化了手术程序，减少了术后并发症，并促进了胃穿孔的愈合过程。这项工作为各种生物医学应用的生物环境适应性功能材料的开发提供了有益的见解。
Developing effective internal wound dressing materials is important for postoperative tissue regeneration while remains a challenge due to the poor biological environment-adaptability of conventional materials. Here, we report an example of injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly, and have explored its application for gastric perforation healing. By leveraging the gastric environment-modulated supramolecular interactions, the self-assembled hydrogel network is orchestrated with sensitive thermo-responsibility, injectability, printability and rapid self-healing capability. The hydrogel dressing can effectively inhibit the attachment of microorganisms and demonstrates outstanding antibiofouling property. In vivo rat model further demonstrates the as-prepared hydrogel dressing simplifies the surgical procedures, reduces postoperative complications as well as enhances the healing process of gastric perforation compared with the conventional treatment. This work provides useful insights into the development of biological environment-adaptive functional materials for various biomedical applications.