Lateral signaling enhances TGF-beta response complexity.
Lateral signaling enhances TGF-beta response complexity.
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横向信号传导增强了 TGF-β 反应的复杂性。
DOI：
10.1016/j.tcb.2004.01.001
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发表时间：
2004
影响因子：
19
通讯作者：
Roberts,AnitaB
中科院分区：
文献类型：
--
作者：
Byfield,StaceyDaCosta;Roberts,AnitaB
TGF-β增强了环境依赖性和细胞特异性作用，这些作用经常出现冲突，例如刺激或抑制生长、凋亡或分化。令人困惑的是，TGF-β与单一受体复合物的结合如何导致如此多样化的反应，该受体复合物激活依赖于Smad转导蛋白从受体到细胞核的穿梭的看似简单的信号转导方案。在这里，我们讨论了一种新的范式TGF-β信号在内皮细胞中，相同的配体可以诱导相反的效果介导的两种不同类型的Smads通过嵌合受体复合物的激活。
TGF-β elicits context-dependent and cell-specific effects that often appear conflicting, such as stimulation or inhibition of growth, apoptosis or differentiation. It is puzzling how such a diverse array of responses can result from binding of TGF-β to a single receptor complex that activates a seemingly straightforward signal-transduction scheme dependent on shuttling of Smad transducer proteins from the receptor to the nucleus. Here, we discuss a novel paradigm for TGF-β signaling in endothelial cells in which the same ligand can induce opposing effects mediated by activation of two different classes of Smads through a chimeric receptor complex.