Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women
Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women
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DOI：
10.1111/j.1365-2265.2005.02288.x
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发表时间：
2005-06-01
影响因子：
3.2
通讯作者：
Nordin, BEC
中科院分区：
文献类型：
--
作者：
Need, AG;O'Loughlin, PD;Nordin, BEC
目的由于已有研究表明母亲或婴儿服用维生素D可以预防儿童I型糖尿病，糖尿病在血清维生素D水平低的成年人中更常见，胰岛素的分泌和作用与健康年轻人的维生素D水平有关，我们研究了门诊患者血清维生素D代谢产物与空腹血糖之间的关系。测量体重和身高，血清25-羟基维生素D [25（OH）D]，血清1，25-二羟基维生素D [1，25（OH）（2）D]，结果空腹血糖与年龄呈正相关，（P < 0.05），体重（P < 0.001）和体重指数（BMI）血清25（OH）D呈负相关（P <0.001），但与血清1，25（OH）（2）D、PTH、肌酐均无显著相关性。当空腹血糖与年龄、BMI和25（OH）D同时回归时，血糖仍是25（OH）D的反函数（P = 0.006）。结论在25（OH）D测定范围内，空腹血糖随25（OH）D水平的下降而升高，但25（OH）D低于40 nmol/l时升高幅度最大。
Objective Because it has been reported that vitamin D, given to mother or infant, can prevent type I diabetes in children, that diabetes is more common in adults with low serum vitamin D and that insulin secretion and action are related to vitamin D levels in healthy young adults we examined the relationship between serum vitamin D metabolites and fasting serum glucose in patients attending our outpatient clinics.Design Retrospective examination of convenience sample of postmenopausal women attending our osteoporosis clinics.Patients A total of 753 postmenopausal women attending a university hospital outpatient clinic and not on any treatment known to affect glucose metabolism.Measurements Body weight and height, serum 25-hydroxyvitamin D [25(OH)D], serum 1,25-dihydroxyvitamin D [1,25(OH)(2)D], serum PTH and fasting serum glucose.Results On simple correlation fasting serum glucose was a positive function of age (P < 0.05), weight (P < 0.001) and body mass index (BMI) (P < 0.001) and a negative function of serum 25(OH)D (P < 0.001), but it was not significantly related to either serum 1,25(OH)(2)D, PTH or creatinine. When fasting serum glucose was regressed simultaneously on age, BMI and 25(OH)D, glucose was still an inverse function of 25(OH)D (P = 0.006).Conclusions Fasting serum glucose increased as 25(OH)D levels fell throughout the range of serum 25(OH)D measured but the greatest increase was observed in those with 25(OH)D below 40 nmol/l.