Immunogenetics of Severe Respiratory Infections: Models for the Development of New Therapeutic Strategies
Immunogenetics of Severe Respiratory Infections: Models for the Development of New Therapeutic Strategies
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DOI：
10.1159/000087666
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发表时间：
2005-09
期刊：
影响因子：
3.7
通讯作者：
M. Bocchino;A. Marruchella;C. Saltini
中科院分区：
文献类型：
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作者：
M. Bocchino;A. Marruchella;C. Saltini
先天性和适应性免疫在肺和其他暴露于微生物的粘膜表面的防御中起着关键作用。抗微生物肽和蛋白质、细胞因子和趋化因子是重要的免疫武器，因为它们建立了呼吸道的保护阵线。感染性疾病的易感性可能是遗传的这一概念已被广泛接受，因为未能激活适应性免疫可能会使感染得以建立并向入侵和传播的方向发展，因此认识到影响免疫系统克服入侵病原体的能力的特定基因缺陷可能会揭示那些发挥最关键作用的免疫调节机制。本综述的目的是讨论感染免疫遗传学的一些进展，这些进展可能导致确定新的抗感染和抗炎药物开发的新策略。
Innate and adaptive immunity plays a critical role in the defence of the lung and other mucosal surfaces exposed to micro-organisms. Anti-microbial peptides and proteins, cytokines and chemokines are important immune weapons as they build up the protective front for the respiratory tract. The notion that susceptibility to infectious diseases may be inherited is widely accepted and, as it is the failure to activate adaptive immunity that may allow infection to become established and progress toward invasion and dissemination, the recognition of specific gene defects affecting the ability of the immune system to overcome invading pathogens may shed light upon those mechanisms of immune regulation that are playing the most critical roles. The aim of the present review is to discuss some of the advances in infection immunogenetics that may lead to identify new strategies in the development of new anti-infectious and anti-inflammatory drugs.