A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.
A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.
复制标题
用两性离子表面涂层赋予生物材料器件的一种简便而通用的方法。
DOI：
10.1002/adhm.201601091
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发表时间：
2017-02
影响因子：
10
通讯作者：
Anderson DG
中科院分区：
文献类型：
--
作者：
Yesilyurt V;Veiseh O;Doloff JC;Li J;Bose S;Xie X;Bader AR;Chen M;Webber MJ;Vegas AJ;Langer R;Anderson DG
Host immune response leading to fibrosis of implanted biomaterials and devices can significantly limit implant performance and life span. The surface physicochemical properties of implanted materials play an important role in modulating this fibrotic response. Here, we demonstrate the surface modification of model devices with zwitterionic phosphorylcholine polymer through mussel-mimetic catecholamine polymer thin films. Using this method, we successfully modify the surfaces of alginate hydrogel microspheres to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice We demonstrate that this facile coating method can be extended to other solid biomaterials, such as polystyrene microspheres, a model material known to produce robust foreign body responses and fibrosis, as a platform approach to improve biocompatibility and reduce fibrosis in vivo. The surface modification of model biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice. It is also demonstrated that this facile coating method can be used as a platform approach to improve biocompatibility and reduce fibrosis in vivo.
