Increased expression of the 58-kD microspherule protein (MSP58) is correlated with poor prognosis in glioma patients
Increased expression of the 58-kD microspherule protein (MSP58) is correlated with poor prognosis in glioma patients
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58 kD 微球蛋白 (MSP58) 表达增加与神经胶质瘤患者预后不良相关
DOI：
10.1007/s12032-013-0677-6
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发表时间：
2013-08
期刊：
影响因子：
3.4
通讯作者：
Fei, Zhou
中科院分区：
文献类型：
--
作者：
Lin, Wei;Li, Xiao-Ming;Zhang, Jing;Huang, Yi;Wang, Jiang;Zhang, Jian;Jiang, Xiao-Fan;Fei, Zhou
人脑胶质瘤的病理分级系统通常被用来评估胶质瘤患者的预后。但是，一些级别相似的胶质瘤患者的生存率存在明显差异。因此，有必要确定一些新的某些肿瘤生物标志物，比分级系统更适合于胶质瘤的预后评估。58 kD微球蛋白（MSP 58）是一种进化上保守的核蛋白，在细胞增殖和恶性转化的调控中起重要作用。然而，MSP 58是否可以作为一个生物标志物来评估胶质瘤患者的恶性程度和预后尚不清楚。在本研究中，我们进行了免疫组织化学分析，以评估MSP 58蛋白在158例人脑胶质瘤和34例正常对照脑组织中的表达。与正常脑组织相比，MSP 58在脑胶质瘤组织中的表达明显增高（P< 0.05），且随病理分级的增高而增高（P< 0.001）。Kaplan-Meier分析显示，MSP 58高表达者生存率低（P< 0.001）。在多因素分析中，MSP 58的高表达也是影响胶质瘤患者总生存率的独立不利预后因素（P< 0.001，危险比8.177，95%CI 2.571-26.008）。结论：MSP 58的高表达与胶质瘤的恶性程度和预后有关。MSP 58作为胶质瘤恶性程度的指标和胶质瘤患者临床结局的预后因子都是有价值的。
The pathological grading system for human gliomas is usually used to evaluate the prognosis of glioma patients. However, some glioma patients with similar grades have obvious discrepancies in survival. It is therefore necessary to identify some new certain tumor biomarkers that are more suitable for the prognostic assessment of gliomas than the grading system. The 58-kD microspherule protein (MSP58) is an evolutionarily conserved nuclear protein and plays an important role in the regulation of cell proliferation and malignant transformation. However, whether MSP58 can be used as a biomarker to evaluate the malignancy and the prognosis of glioma patients is unknown. In the present study, we performed immunohistochemical analysis to evaluate MSP58 protein expression in 158 specimens of human gliomas and 34 normal control brain tissues. Compared with the control tissues, MSP58 expression was not only significantly higher in the glioma tissues (P< 0.05), but also increased with the increasing pathological grade (P< 0.001). Furthermore, the Kaplan–Meier analysis showed that high expression of MSP58 could predict poor survival in glioma patients (P< 0.001). In the multivariate analysis, high expression of MSP58 was also an independent unfavorable prognostic factor for the overall survival in glioma patients (P< 0.001, hazard ratio, 8.177, 95 % CI 2.571–26.008). In conclusion, the increased expression of MSP58 is correlated with a higher malignant grade and poor prognosis in glioma patients. MSP58 is valuable both as an indicator of the malignancy of gliomas and as a prognostic factor for the clinical outcome of glioma patients.
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RNAi 介导的 MSP58 抑制可降低人神经胶质瘤细胞系中的肿瘤生长、迁移和侵袭
影响因子：
5.3
作者：
Lin W;Zhang J;Zhang J;Liu X;Fei Z;Li X;Davidovic L;Tang Z;Shen L;Deng Y;Yang A;Han H;Zhang X;Yao L
通讯作者：
Yao L
影响因子：
2.4
作者：
McNeill, Katharine A.
通讯作者：
McNeill, Katharine A.
影响因子：
3.6
作者：
Du, Xiulian;Wang, Qiang;Greene, Mark I.
通讯作者：
Greene, Mark I.
影响因子：
7
作者：
Lehner, B;Sanderson, CM
通讯作者：
Sanderson, CM
DOI：
10.1046/j.1432-1327.1998.2530734.x
发表时间：
1998-05-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Ren, Y;Busch, RK;Busch, H
通讯作者：
Busch, H