Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer
Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer
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DOI：
10.1016/j.cancergencyto.2004.03.015
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发表时间：
2004-11-01
影响因子：
--
通讯作者：
Thibodeau, SN
中科院分区：
文献类型：
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作者：
Debes, JD;Yokomizo, A;Thibodeau, SN
一些报告表明，谷胱甘肽-S-转移酶（GST）家族的酶涉及各种癌症，由于其致癌物解毒特性。pi变体（GSTP 1 I105 V）的密码子105中的多态性影响酶的酶活性，其与来自不同器官的癌症的发生率有关。然而，已发表的前列腺癌（PCa）数据存在争议。一些研究报告与GSTP 1 I105 V多态性和散发性前列腺癌的关联，而其他研究报告没有关联。最近，一项研究表明，日本人群中GSTP 1 I105 V多态性与家族性PCa呈正相关。在本研究中，我们评估了美国人群中GSTP 1 I105 V多态性与家族性和散发性前列腺癌的相关性。我们分析了438例家族性前列腺癌，499例散发性前列腺癌，和5 - 10对照组的DNA样本。与对照组相比，我们没有发现GSTP 1 I105 V多态性与家族性或散发性PCa之间存在显著相关性[比值比（OR）1.0（0.74-1.37）; P = 0.58]。此外，在诊断年龄、Gleason分级或淋巴结受累分层后，未发现相关性[OR = 0.84（0.65-1.09），P = 0.37]。这些数据表明，有没有散发性或家族性前列腺癌在美国家庭含有GSTP 1 I105 V多态性的相关风险。(C)2004年爱思唯尔公司All rights reserved.
Several reports suggest that the glutathione-S-transferase (GST) family of enzymes is involved in a variety of cancers, due to their carcinogen-detoxification properties. A polymorphism in codon 105 of the pi variant (GSTP1 I105V), which affects the enzymatic activity of the enzyme, has been linked to the incidence of cancers from different organs. However, the published data in prostate cancer (PCa) is controversial. Some studies report an association with the GSTP1 I105V polymorphism and sporadic PCa, whereas other studies report no association. Recently, one study showed a positive correlation between the GSTP1 I105V polymorphism and familial PCa in a Japanese population. In the present study, we assessed the correlation of the GSTP1 I105V polymorphism with familial and sporadic PCa in an American population. We analyzed DNA samples from 438 patients with familial PCa, 499 patients with sporadic PCa, and 5 10 controls. We found no significant association between the GSTP1 I105V polymorphism and familial or sporadic PCa when compared to the control group [odds ratio (OR) 1.0 (0.74-1.37); P = 0.58]. Moreover, no association was found after stratification for age of diagnosis, Gleason grade, or lymph node involvement [OR = 0.84 (0.65-1.09), P = 0.37]. These data indicate that there is no associated risk for sporadic or familial PCa in American families containing the GSTP1 I105V polymorphism. (C) 2004 Elsevier Inc. All rights reserved.