Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain.
Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain.
复制标题
来自环境驱动的表观遗传变化的动物模型的洞察力和成人大脑的洞察力。
DOI：
10.1017/s095457941600081x
复制
发表时间：
2016-11
影响因子：
3.3
通讯作者：
Roth TL
中科院分区：
文献类型：
--
作者：
Doherty TS;Roth TL
许多神经科学家致力于理解大脑和行为的明显可塑性。近年来，表观遗传学已成为这一焦点的核心，作为行为修改的主要机制候选人。动物模型在推进我们对发育和成人大脑中表观基因组变化的环境驱动的理解方面发挥了重要作用。这篇评论主要集中在这样的发现驱动的不利环境沿着其相关的行为结果。虽然讨论的大部分证据都集中在中枢神经系统内的表观遗传学上，但也强调了对经历过重大逆境的人类进行的几项外周研究。随着我们不断解开表观遗传学和表型之间的联系，识别环境诱导的表观遗传变化的复杂性和特异性是理解最佳发育以及如何预防或改善破坏性环境所产生的行为缺陷的重要一步。
The efforts of many neuroscientists are directed toward understanding the appreciable plasticity of the brain and behavior. In recent years, epigenetics has become a core of this focus as a prime mechanistic candidate for behavioral modifications. Animal models have been instrumental in advancing our understanding of environmentally-driven changes to the epigenome in the developing and adult brain. This review focuses mainly on such discoveries driven by adverse environments along with their associated behavioral outcomes. While much of the evidence discussed focuses on epigenetics within the central nervous system, several peripheral studies in humans who have experienced significant adversity are also highlighted. As we continue to unravel the link between epigenetics and phenotype, discerning the complexity and specificity of epigenetic changes induced by environments is an important step toward understanding optimal development and how to prevent or ameliorate behavioral deficits bred by disruptive environments.