Synchrotron radiation circular-dichroism spectroscopy as a tool for investigating protein structures
Synchrotron radiation circular-dichroism spectroscopy as a tool for investigating protein structures
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DOI：
10.1107/s0909049500009262
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发表时间：
2000-09-01
影响因子：
2.5
通讯作者：
Wallace, BA
中科院分区：
文献类型：
--
作者：
Wallace, BA
本文综述了使用同步辐射圆二色性（SRCD）光谱检查蛋白质结构，讨论传统的圆二色性和SRCD之间的差异，以及SRCD研究揭示了蛋白质结构的例子。它进一步讨论了该技术的未来潜力，包括在结构基因组学，膜蛋白结构阐明，晶体学研究的关系，蛋白质折叠和动力学的作用。
This paper reviews the use of synchrotron radiation circular dichroism (SRCD) spectroscopy for examining protein structures, discussing the differences between conventional circular dichroism and SRCD, as well as examples of what SRCD studies have revealed about protein structures to date. It further discusses the future potential of the technique, including roles in structural genomics, membrane protein structure elucidation, relationships to crystallographic studies, and protein folding and dynamics.