A General Synthetic Approach for Obtaining Cationic and Anionic Inorganic Nanoparticles via Encapsulation in Amphiphilic Copolymers
A General Synthetic Approach for Obtaining Cationic and Anionic Inorganic Nanoparticles via Encapsulation in Amphiphilic Copolymers
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DOI：
10.1002/smll.201100509
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发表时间：
2011-10-17
期刊：
影响因子：
13.3
通讯作者：
Parak, W. J.
中科院分区：
文献类型：
--
作者：
Geidel, C.;Schmachtel, S.;Parak, W. J.
合成了一系列主链上具有可变电荷密度的两亲性共聚物。带正电荷的 N,N,N-三甲基铵-2-乙基甲基丙烯酸碘化物或带负电荷的 2-(甲基丙烯酰氧基)乙基膦酸和甲基丙烯酸月桂酯用作结构单元。当包裹在疏水性封端的无机纳米粒子（NP）周围时，后者能够分散在水溶液中。使用这种方法，可以以可靠的方式合成带正电和带负电的胶体纳米粒子。本文提出的方法允许通过使用具有可变比例的带电单体和甲基丙烯酸月桂酯的聚合物将NP上的电荷调节至不同的负值和正值。事实上，所有类型的疏水性无机纳米颗粒都可以用这些两亲性聚合物进行涂覆。演示了 Au 颗粒以及 CdSe/ZnS 量子点的涂层程序。迄今为止，将两亲性聚合物包裹在纳米粒子周围仅产生阴离子纳米粒子。这项工作中合成的聚合物允许带正电荷的纳米颗粒具有高胶体稳定性。
A series of amphiphilic copolymers with variable charge densities on their backbone is synthesized. Positively charged N,N,N-trimethylammonium-2-ethyl methacrylate iodide or negatively charged 2-(methacryloyloxy) ethylphosphonic acid and lauryl methacrylate are used as building blocks. When wrapped around hydrophobically capped inorganic nanoparticles (NPs), the latter are able to disperse in aqueous solutions. Using this method, positively as well as negatively charged colloidal NPs can be synthesized in a reliable way. The method presented herein allows the charge on the NPs to be adjusted to different negative and positive values by using polymers with a variable ratio of charged monomers and lauryl methacrylate. Virtually all kinds of hydrophobic inorganic NPs could be coated with these amphiphilic polymers. The coating procedure is demonstrated for Au particles as well as for CdSe/ZnS quantum dots. To date, wrapping amphiphilic polymers around NPs has led only to anionic NPs. The polymers synthesized in this work allow for positively charged NPs with a high colloidal stability.