Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes
Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes
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DOI：
10.1139/apnm-2013-0133
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发表时间：
2014-02-01
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影响因子：
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通讯作者：
Ramirez-Emiliano, Joel
中科院分区：
文献类型：
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作者：
Franco-Robles, Elena;Campos-Cervantes, Alejandra;Ramirez-Emiliano, Joel
我们评估了姜黄素治疗对糖尿病db/db小鼠（DM）海马和额叶皮质（FC）以及肥胖人血清中蛋白质氧化（PO）、脂质过氧化（LP）和脑源性神经营养因子（BDNF）水平的影响。因此，在8周期间每天用50 mg/kg姜黄素治疗DM。每天用500和750 mg姜黄素口服给药治疗肥胖人12周;在治疗的第0、2、6和12周测定血清中BDNF、PO和LP水平。与未治疗的野生型小鼠相比，DM小鼠海马和FC中BDNF水平降低。姜黄素改善或恢复糖尿病患者的BDNF水平至正常水平，但姜黄素对肥胖患者血清中的BDNF水平没有任何影响。在DM组海马和FC中，高脂血症和姜黄素对LP水平无影响。高血脂增加海马和FC的PO水平，而姜黄素降低海马，但不FC的这些水平。在肥胖人群的血清中，与基础水平相比，500 mg剂量在第6周和第12周降低了LP水平，但750 mg剂量没有任何影响;与基础水平相比，两种剂量的姜黄素在治疗的第2周，第6周和第12周降低了PO水平。目前的研究结果表明，姜黄素的治疗潜力，以减少人类肥胖引起的氧化，也表明姜黄素恢复糖尿病的BDNF水平。
We evaluated the effects of curcumin treatment on protein oxidation (PO), lipid peroxidation (LP) and brain-derived neurotrophic factor (BDNF) levels in the hippocampus and frontal cortex (FC) of diabetic db/db mice (DM) and in sera of obese humans. Thus, DM were treated daily with 50 mg/kg of curcumin during an 8-week period. Obese human were treated daily with 500 and 750 mg of curcumin that was administered orally for 12 weeks; BDNF, PO and LP levels in sera were determined at in weeks 0, 2, 6 and 12 of treatment. BDNF levels decreased in hippocampus and FC of DM as compared with untreated wild-type mice. Curcumin improved or restored BDNF levels to normal levels in DM, but curcumin did not have any effect on BDNF levels in sera of obese humans. In hippocampus and FC of DM, hyperglycaemia and curcumin did not have effect on LP levels. Hyperglycaemia increased PO levels in hippocampus and FC, whereas curcumin decreased these levels in hippocampus but not in FC. In sera of obese humans, the 500-mg dose decreased LP levels in weeks 6 and 12 when compared with basal levels, but the 750-mg dose did not have any effect; both doses of curcumin decreased PO levels in weeks 2, 6 and 12 of treatment when compared with basal levels. Present results suggest a therapeutic potential of curcumin to decrease oxidation caused by obesity in humans and also show that curcumin restores BDNF levels in DM.