Local spinal cord glucose utilization in conscious and halothane-anaesthetized rats.
Local spinal cord glucose utilization in conscious and halothane-anaesthetized rats.
复制标题
清醒和氟烷麻醉大鼠的局部脊髓葡萄糖利用。
DOI：
10.1007/bf03010856
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Atlas,S
中科院分区：
文献类型：
--
作者：
Crosby,G;Atlas,S
作者使用2-[14 C]脱氧葡萄糖方法研究了成年Sprague-Dawley大鼠在1.2%氟烷麻醉期间的局部脊髓和大脑葡萄糖利用率。在清醒的动物（n = 5），腰椎灰质的葡萄糖利用率比大脑皮质低约50%。氟烷麻醉（n = 6）降低脊髓和脑代谢率。脊髓葡萄糖利用率降低了12- 35%，但这低于氟烷在16个大脑结构中的8个中产生的45- 70%的降低，并且与产生的低血压无关。这些结果表明，氟烷是一种脊髓代谢抑制剂，但其对该组织的影响远小于对许多大脑结构的影响。
The authors used the 2-[14C]deoxyglucose method to study local spinal and cerebral glucose utilization simultaneously during 1.2 per cent halothane anaesthesia in adult Sprague-Dawley rats. In conscious animals (n = 5) the rate of glucose utilization in lumbar spinal gray matter was about 50 per cent lower than that of cerebral cortex. Halothane anaesthesia (n = 6) reduced spinal cord and cerebral metabolic rate. Spinal glucose utilization was reduced 12-35 per cent, but this was less than the 45-70 per cent decrease halothane produced in 8 of 16 cerebral structures examined and was independent of the hypotension produced. These results indicate that halothane is a spinal metabolic depressant but that its effects on this tissue are substantially less than those it has on many cerebral structures.