The role of a group III AQP, AQP11 in intracellular organelle homeostasis.
The role of a group III AQP, AQP11 in intracellular organelle homeostasis.
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DOI：
10.2152/jmi.56.312
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
K. Ishibashi;S. Koike;Shintaro Kondo;Shigeki Hara;Yasuko Tanaka
中科院分区：
文献类型：
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作者：
K. Ishibashi;S. Koike;Shintaro Kondo;Shigeki Hara;Yasuko Tanaka
AQP11是一个新的水通道蛋白亚家族成员，包括许多氨基酸同源性较低的水通道蛋白同源物，约占先前鉴定的AQP的20%。虽然这些AQP有不寻常的NPA序列，这些AQP有一个完全保守的和功能上不可或缺的半胱氨酸残基下游的第二个NPA框，这表明他们属于一个特定的AQP亚家族，我们建议命名为组III AQP。另一方面，NPA盒在以前的AQP亚家族中高度保守：I组AQP，原始水选择性水通道蛋白家族和II组AQP，水甘油通道蛋白家族。目前，III组AQP的作用仅与AQP11有关，因为小鼠细胞内定位的AQP11的破坏在近端小管中产生巨大的空泡，导致在一个月大时致命的多囊肾。本文就水通道蛋白的一级结构分类进行综述，以期对水通道蛋白的功能和作用有更深入的了解。随着基因组计划中新的AQP样序列的积累，这种分类将有助于预测它们的功能，因为每组在其功能，分布和调节方面可能具有特定的特征。
AQP11 is a member of a new aquaporin subfamily which includes many aquaporin homologs with low amino acid identities, around 20% of previously identified AQPs. Although these AQPs have unusual NPA sequences, these AQPs have a completely conserved and functionally indispensable cysteine residue downstream of the second NPA box, suggesting that they belong to a specific AQP subfamily, which we propose to name the group III AQPs. On the other hand, the NPA boxes are highly conserved in previous AQP subfamilies: the group I AQPs, original water-selective aquaporin family and the group II AQPs, aquaglyceroporin family. Currently the roles of the group III AQPs are only known with AQP11 as the disruption of intracellularly located AQP11 in mice produced huge vacuoles in the proximal tubule leading to fatal polycystic kidneys at one month old. This review focused on the classification of AQPs based on primary structures to obtain insights into the function and the role of AQPs. With the accumulation of new AQP-like sequences through genome projects, this classification will be useful to predict their functions as each group may have specific characteristics in its function, distribution and regulation.