NOSOCOMIAL ADENOVIRUS INFECTIONS - MOLECULAR EPIDEMIOLOGY OF AN OUTBREAK DUE TO ADENOVIRUS-3A
NOSOCOMIAL ADENOVIRUS INFECTIONS - MOLECULAR EPIDEMIOLOGY OF AN OUTBREAK DUE TO ADENOVIRUS-3A
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DOI：
10.1093/infdis/158.2.423
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发表时间：
1988-08-01
影响因子：
6.4
通讯作者：
JORDAN, MC
中科院分区：
文献类型：
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作者：
BRUMMITT, CF;CHERRINGTON, JM;JORDAN, MC
一名免疫功能低下的妇女死于3型腺病毒引起的播散性感染。在她住院期间和她去世后，38名医院工作人员患上了急性呼吸道疾病。腺病毒3型感染记录的文化，在18个38个人和血清转化的一个额外的雇员。在接触指示病例的34名无症状医院工作人员中，有4人也发生了血清转化。因此，23名人员被认为已确诊感染，其中22人报告与指示病例有直接接触。感染的获得与接触的数量和类型有关。对感染的保护与早期血清学样本中可检测到的血清中和抗体有关。用6种不同的核酸内切酶进行限制性内切酶分析表明，所有分离的病毒均为3a型，具有相同的遗传组成。这项研究强调了腺病毒作为医院感染原因的重要性，并表明病毒DNA的遗传分析是研究共同来源爆发的有力工具。
An immunocompromised woman died of disseminated infection due to adenovirus type 3. During her hospitilization and after her death, 38 hospital personnel developed an acute respiratory illness. Adenovirus type 3 infection was documented by culture in 18 of the 38 individuals and by seroconversion in one additional employee. Four of 34 asymptomatic hospital personnel exposed to the index case also seroconverted. Thus, 23 personnel were considered to have confirmed infections, and 22 of these 23 reported direct contact with index case. Acquisition of infection was associated with the number and type of contacts. Protection against infection was associated with detectable serum neutralizing antibody in the early serological sample. Restriction enzyme analysis using six different endonucleases indicated that all isolates of virus were type 3a and had identical genetic composition. This study underscores the importance of adenovirus as a cause of nosocomial infection and indicates that genetic analysis of viral DNA is a powerful tool for studying common-source outbreaks.